Bronchoscopic lung volume reduction using an endobronchial valve to treat a huge emphysematous bullae: a case report

In patients with chronic obstructive pulmonary disease (COPD), bronchoscopic lung volume reduction (BLVR) techniques using unidirectional endobronchial valves improve lung function and increase exercise tolera...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Case report Source Type: research

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CONCLUSIONS: Patients with symptomatic COPD treated with TLD combined with optimal pharmacotherapy had fewer study defined respiratory adverse events, including hospitalizations for COPD exacerbation. Clinical trial registration available at clinicaltrials.gov, ID: NCT02058459. PMID: 31404499 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
We describe a 66‐year‐old man with severe chronic obstructive pulmonary disease (COPD) who faile d assessments for BLVR because of the inability to perform the carbon monoxide diffusion test but subsequently had EBV deployed to his right upper lobe bronchi for persistent air leak complicating a spontaneous pneumothorax. Afterwards, there was subjective improvement in breathlessness, exercise ca pacity, and reduced frequency of exacerbations requiring hospitalization. Lung function parameters showed marked improvement. This case suggests that patients with compatible spirometric lung volume and computed tomography findi...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
We present two cases of patients with chronic obstructive lung disease (COPD) who developed different forms of pulmonary amyloidosis. In both cases malignancy was considered as primary diagnosis. Transthoracic biopsy confirmed pulmonary amyloidosis.In the first case the patient presented with progressive dyspnoea over a two years period. Initial assessment was consistent with a diagnosis of COPD but progressive changes in symptoms and lung functions and subsequently CT Thorax revealed possible airway obstruction. Bronchoscopy confirmed an obstructive lesion initially considered to be malignant but was found to be due to tr...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Rationale: Rigid bronchoscopy under general anesthesia enables performing diagnostic and/or therapeutic procedures in the tracheobronchial tree. As most patients undergoing rigid bronchoscopy have moderate to severe respiratory disease or central airway obstruction, the operators often face the risk of hypoxemia when inserting the rigid bronchoscope into the patients’ airway. Applying high flow nasal cannula (HFNC) oxygen therapy before the insertion of the bronchoscope allows to maintain high fractional inspired oxygen (FiO2) and thus leading to maximizing apnea time before desaturation. Patient concerns and diag...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Chronic obstructive pulmonary disease is a condition characterized by progressive airflow limitation caused by airway and parenchymal inflammation. Current medical therapies, including bronchodilators, corticosteroids, and anti-inflammatory medications, have been shown to variably improve pulmonary function or quality of life without providing a long-term mortality benefit. Mortality benefits to therapy have been demonstrated in only 2 therapeutic interventions to date: long-term use of daily supplemental oxygen and surgical lung volume reduction (LVRS) for upper-lobe–predominant disease in patients with a low baseli...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Symposium: Imaging of Innovative and Contemporary Thoracic Interventions: State-of-the-Art Source Type: research
Conclusions: CT-derived lobar volume and emphysema quantification using the LungSeg program is efficient and reliable in allowing lobar volume assessment. LungSeg has low inter-user variability and agrees better with plethysmography for COPD assessment in our study.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
Conclusions: The results demonstrate acceptable safety and feasibility of TLD in patients with COPD, with improvements in adverse event rates after procedural enhancements.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
Condition:   COPD Intervention:   Procedure: Bronchoscopy Sponsors:   University of Virginia;   GlaxoSmithKline Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: Development of novel approaches for detecting activated macrophages in patients could lead to important advances in studying and treating lung diseases, including COPD. Our studies will develop a novel imaging approach to monitor inflammation in COPD and provide information regarding disease severity and progression. Identifying patients with high levels of macrophage activation could delineate subgroups of patients who would benefit from anti-inflammatory or macrophage-targeted therapies. In addition, measuring macrophage activation in COPD will help to characterize the mechanistic roles of macrophages in this disease.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research
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