Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens

Conclusions: This large-scale assessment (n = 244) is the first demonstration of efficacy for CL delivery of a therapeutic for ocular allergy. Results are comparable to direct topical drug delivery and suggest that the lens/ketotifen combination can provide a means of simultaneous vision correction and treatment for CL wearers with ocular allergies.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research

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Eczema, atopic dermatitis, urticaria, and other inflammatory allergic cutaneous reactions cause itch. Itch often makes the patients scratch their skin, and persistent scratching can aggravate dermal conditions. Itch can even cause emotional disturbance and sleep loss. The management of itch is therefore a key component of the clinical treatment of patients with allergies.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody (Ab) response against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which is present in glycoproteins from tick saliva and tissues of non-catarrhine mammals. Recurrent tick bites induce high levels of anti-α-Gal IgE Abs that mediate delayed hypersensitivity to consumed red meat products in humans. Initially, it was thought that the origin of tick-derived α-Gal was either residual blood meal mammalian glycoproteins containing α-Gal or tick gut bacteria producing this glycan. However, recently tick ga...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: We present the case of allergic contact dermatitis (ACD) due to hypersensitivity to fentanyl with good tolerance to buprenorphine. Positive PT in this patient suggests a type IV hypersensitivity mechanism. Allergic reactions to opioids are frequently immediate, but delayed reactions could appear, especially when the drug is administered topically. PMID: 31131754 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Listen to the Podcast or Read the Transcript [00:00:03] Hi I’m Dr. Alan Greene pediatrician and I’d like to talk with you tonight about The Brain Stage. [00:00:10] I remember vividly when I was a pediatric resident in training go to a Grand Rounds about a surprising topic. [00:00:18] The function of the brain and the function of the skin and one of the things that dermatologists talked about was a common procedure freezing warts. Freezing warts was then, and is still, one of the most common ways to get rid of warts. What she talked about was how wildly different the results were in different studies. People use...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Dr. Greene's Blog Uncategorized Cephalic Phase Placebo The Brain Stage Source Type: blogs
This paper explores the interrelationship of acute stress, itch, and scratching in patients with atopic dermatitis, providing new insights on the mechanism of stress-related exacerbation of itch.The British Journal of Dermatology
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Dermatology Journal Article Source Type: news
Benadryl (diphenhydramine) is a brand-name, over-the-counter product that's typically used to relieve symptoms of hay fever (seasonal allergies), other allergies, and the common cold. It's also used to relieve itchy skin due to insect bites, hives, and other causes. Learn about side effects, warnings, dosage, and more.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Allergy Source Type: news
This article reports on a 51-year-old Austrian male who acquired a tick bite in Austria in spring 2017, which, within 48 h, resulted in prolonged inflammation of the skin area around the bite. The patient experienced an allergic reaction 3 months later approximately 8 h after eating a medium rare steak for dinner. The symptoms included an itchy rash on both sides of the torso and on both arms which persisted for several hours. In spring 2018, the patient suffered another tick bite. The patient's skin reaction was similar to that of the previous year. In the following months, the patient experienced five episo...
Source: Wiener Klinische Wochenschrift - Category: General Medicine Authors: Tags: Wien Klin Wochenschr Source Type: research
ConclusionsAdults with AD had low rates of outpatient and high rates of urgent care, ED, and hospital visits. The major predictor of outpatient utilization for AD care was AD severity. Racial/ethnic, socioeconomic, and/or health care disparities reduce outpatient utilization and increase urgent care, ED, and hospital utilization.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Allergic rhinitis, or hayfever, is a common condition affecting both adults and children. One suggestion for treating it is to rinse the inside of the nose with salt water and the Cochrane Review of the effects of this was published in June 2018. We asked Carl Philpott from the Norwich Medical School in the UK to tell us what he and his co-authors found." Allergic rhinitis is swelling or irritation of the inside of the nose caused by allergies to airborne particles, such as grass pollen or dustmite. It ’s accompanied by symptoms including a blocked, runny or itchy nose, and sneezing.Various treatments have been ...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
AbstractPurpose of reviewAtopic dermatitis (AD) is a chronic eczematous skin disease associated with intense pruritus and skin barrier dysfunction. Not only histamine, but also various pruritogens can induce itch in the skin of AD patients. Among them, one of the potentially endogenous pruritogens in the skin is endothelin-1 (ET-1). To understand the mechanism of action, production, and roles of ET-1 in the skin of AD, we reviewed recent advances in the understanding of ET-1.Recent findingsRecently, functions of ET-1 related to inflammation other than itch have been reported. The expression of ET-1 and IL-25 was found to b...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
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