Rapid Eye Movement Sleep Percentage and Duration in Posttraumatic Stress Disorder Vary Dynamically and Inversely With Indices of Sympathetic Activation During Sleep and Sleep Fragmentation
Posttraumatic stress disorder (PTSD) is associated with activation of the brain fear circuitry. Studies of sleep in PTSD provide a unique window into the relation or connection of sleep physiology and autonomic activation. Serial level 3 home sleep apnea tests (HSATs) (10 HSATs over 1 month) in a patient who was medication free, had PTSD, and had refused positive airway pressure therapy, revealed both percentage of rapid eye movement (REM) sleep (mean± standard deviation [SD]: 19.88%± 10.11%; range 1.94% to 35.01%) and REM sleep duration (minutes) (mean± SD: 73.08± 48.24; range 3.49– 151.59) varied markedly over the 10 HSATs. Both percentage of REM sleep and REM sleep duration correlated negatively with sleep onset latency (r =−.661,P = .037 andr =−.748,P = .013, respectively) and the mean pulse rate during sleep (r =−.667,P = .035 andr =−.771,P = .009, respectively), and positively with sleep efficiency (r = .824,P = .003 andr = .922,P
CONCLUSIONS TOS can be evaluated by CE-MRA, T2-STIR-SPACE, and VIBE during a single examination, with a reduced contrast material dose. This imaging modality performs well in showing the anatomical structure of the neurovascular bundle and the cause of the compression. PMID: 31600179 [PubMed - in process]
CONCLUSION: Despite good interrater variability and convenient usage of the suggested X‑ray assessment system, this approach did not enable the identification of any associations by which a TM and, therefore, a possible straightforward or complicated treatment pathway could be predicted. Attention should possibly be paid to a rotation of the cuff during implantation with a lateral position of the stimulation lead. PMID: 31598770 [PubMed - as supplied by publisher]
Publication date: 2019Source: International Review of Neurobiology, Volume 147Author(s): Jessie S.M. Chan, Siu-Man Ng, Lai-Ping Yuen, Cecilia L.W. ChanAbstractChronic fatigue syndrome (CFS) is often overlooked, has unclear etiology and no effective cure except some symptomatic treatments. Additionally, most people with CFS do not seek medical attention. Qigong exercise, an ancient Eastern body-mind-spirit practice, has been long practiced in Chinese communities and may powerfully trigger the self-healing process. Using full baseline data (n = 1409), the average Hong Kong CFS respondent was found to be female, mar...
iRhythm and Verily announced a partnership last month to “co-develop solutions intended to provide early warning, diagnosis and management for patients, particularly for those with silent or undiagnosed AF.” We spoke with iRhythm CEO Kevi...
MedWatch Alert on certain prescription insomnia medicines.
Condition: Obstructive Sleep Apnea Intervention: Sponsor: Mayo Clinic Recruiting
Conditions: Transcutaneous Electrical Acupoint Stimulation; Thoracoscopic Surgery; Postoperative Sleep Quality Intervention: Other: Transcutaneous Electrical Acupoint Stimulation Sponsor: Shengjing Hospital Recruiting
Condition: Post Traumatic Stress Disorder Interventions: Drug: Brexpiprazole; Drug: Sertraline; Other: Placebo Sponsor: Otsuka Pharmaceutical Development&Commercialization, Inc. Recruiting
Conditions: Down Syndrome; Obstructive Sleep Apnea Intervention: Behavioral: Open-ended semi-structured interviews Sponsors: Children's Hospital of Philadelphia; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI); University of Pennsylvania; Children's Hospital Medical Center, Cincinnati Recruiting
PTSD with dissociative symptoms (DSM-5) is known to be associated with greater PTSD symptom severity, greater psychopathology, and more sleep difficulties. To my knowledge there are no reported studies of polysomnographically measured sleep physiological correlates of dissociation in PTSD patients.