TORn in Two Over Breast Cancer Drug Resistance

Knowing the genetic makeup of patient tumors permits the development of new DNA-based diagnostics, such as BEAMing and PARE. By incorporating these new tools into future trials, we should be able to concurrently learn about drug resistance and significantly improve patient responses.
Source: Cancer Network - Category: Cancer & Oncology Source Type: news

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Source: Clinics - Category: General Medicine Source Type: research
ConclusionEthyl acetate &Water extracts have represented potent activity against Salmonella typhi, Escherichia coli, &Staphylococcus aureus bacteria as well, provided cytotoxicity against tested cancer cell lines. These results can be explored to identify individual phyto-molecules from the extracts for anticancer &antimicrobial potentials to identify new phytomedicines.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
If protective measures were widely adopted, they could significantly reduce women ’s chances of ever getting breast cancer.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Breast Cancer Breasts Estrogen Preventive Medicine Women and Girls Hormones Source Type: news
[The Conversation Africa] Low-income communities in South Africa have the lowest incidence of breast cancer in the country. But they also have the worst health outcomes. Black South African women are the least likely segment of the population to have breast cancer but the most likely to die from it.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Night-shift work has been shown to be associated with breast cancer risk. Might it also play a role in prostate cancer development?American Journal of Epidemiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
SCIENTISTS say they can fight breast cancer by using ultrasound. Doctors would inject minute cell-like bubbles of drugs to travel through the lymphatic system, where the disease spreads.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
I am a firm believer that medicine is best practiced as a team, with the one undergoing treatment at the center participating fully. It ’s a belief embedded in the multidisciplinary care model. I have been fortunate to have been exposed to multidisciplinary clinics in my fellowship at Memorial Sloan Kettering Cancer Center and have worked […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Patient breast cancer Oncology/Hematology Source Type: blogs
AbstractPurpose of ReviewImmune checkpoint blockade (ICB) has changed the clinical course of multiple cancer types and durable responses have now been observed in breast cancer (BC) patients. Most data suggest that, compared to other subtypes, triple-negative BC (TNBC) patients are more responsive to ICB, and anti-PD-L1 therapy is now approved in PD-L1+ metastatic TNBC, in combination with chemotherapy.Recent FindingsNearly 40% of PD-L1+ TNBC patients did not respond to this combination. Thus, additional biomarkers appear to be necessary to more precisely identify potential responders. A comprehensive analysis of the breas...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone.Recent FindingsMCP-1 is a key mediator of osteoclastogenesis, being the highest induced gene during intermittent treatment with parathyroid hormone (iPTH), but also regulates catabolic effects of continuous PTH on bone including monocyte and macrophage recruitment, osteoclast formation and bone resorption. In concer...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
ConclusionsStrengths include an innovative model of referral and funding, through a life insurance provider, the involvement of a multidisciplinary collaborative team to design, develop and implement the pilot, and considerable consumer involvement.Implications for Cancer SurvivorsThe refined intervention will address a critical gap to improve reintegration into work and society, contributing to improved quality of life for cancer survivors in Australia. Models of referral through insurers to rehabilitation services could be adopted in other jurisdictions.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
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