Is a broadly effective dengue vaccine even possible?

(Mary Ann Liebert, Inc./Genetic Engineering News) Dengue is on the rise, with about 20,000 patients dying each year from this mosquito-borne disease, yet despite ongoing efforts a broadly effective dengue vaccine is not available.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Publication date: Available online 13 June 2019Source: Antiviral ResearchAuthor(s): Anna Dubankova, Evzen BouraAbstractYellow fever virus (YFV) is responsible for devastating outbreaks of Yellow fever (YF) in humans and is associated with high mortality rates. Recent large epidemics and epizootics and exponential increases in the numbers of YF cases in humans and non-human primates highlight the increasing threat YFV poses, despite the availability of an effective YFV vaccine. YFV is the first human virus discovered, but the structures of several of the viral proteins remain poorly understood. Here we report the structure ...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 11 June 2019Source: The Lancet Global HealthAuthor(s): Manoj V Murhekar, P Kamaraj, Muthusamy Santhosh Kumar, Siraj Ahmed Khan, Ramesh Reddy Allam, Pradip Barde, Bhagirathi Dwibedi, Suman Kanungo, Uday Mohan, Suman Sundar Mohanty, Subarna Roy, Vivek Sagar, Deepali Savargaonkar, Babasaheb V Tandale, Roshan Kamal Topno, Gajanan Sapkal, C P Girish Kumar, R Sabarinathan, Velusamy Saravana Kumar, Sailaja BitraguntaSummaryBackgroundThe burden of dengue virus (DENV) infection across geographical regions of India is poorly quantified. We estimated the age-specific seroprevalence, force of infecti...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Dengue virus (DENV) is a member of the Flavivirus family that includes Zika virus (ZIKV), West Nile virus, Japanese encephalitis virus, and yellow fever virus. As the most prevalent of the flaviviruses, DENV is responsible for tens of millions of infections each year. The clinical manifestations of infection with one of the four DENV serotypes (DENV1–4) range from no symptoms to hemorrhagic fever and shock (“severe dengue”), which is fatal in ~25,000 patients annually. Many factors contribute to the development of severe dengue, including the DENV serotype and host expression of certain HLA alleles; howev...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study analyses the relationship between weather predictors including its lagged terms, and dengue incidence in the District of Tawau over a period of 12 years, that is from 2006-2017. A forecasting model purposed to predict future outbreaks in Tawau was then developed using this data. Monthly dengue incidence data, mean temperature, maximum temperature, minimum temperature, mean relative humidity and mean rainfall over a period of 10 years from 2006-2017 in Tawau were retrieved from Tawau District Health Office and Malaysian Meteorological Department, Sabah Branch. Cross-correlation analysis between weat...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Memory B-cells (MBCs) are potential antibody secreting immune cells that differentiate and mature following host exposure to a pathogen. Following differentiation, MBCs remain in peripheral circulation after recovery and are poised to secrete antigen-specific antibodies if and when they are re-exposed to their cognate antigen. Consequently, MBCs form the founder population and provide one of the first lines of pathogen-specific defense against reinfection. The role MBCs play is complicated for viruses that are heterologous, such as dengue virus (DENV), which exist as antigenically different serotypes. On second infection w...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The FDA hasapproved the first vaccine to prevent disease caused by all 4 dengue virus serotypes. The vaccine is indicated only for children and teens aged 9 to 16 years living in endemic areas who have had a previous, laboratory-confirmed dengue infection.
Source: JAMA - Category: General Medicine Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Publication date: Available online 29 May 2019Source: International Journal of Pediatrics and Adolescent MedicineAuthor(s): Tracy Evans-GilbertAbstractChikungunya (CHIKV), Zika (ZIKV), and Dengue viruses (DENV) exhibit similar ecological, evolutionary, and epidemiological patterns but have different pathophysiological mechanisms of disease manifestations. Clinical presentations overlap and can be asymptomatic. Differences occur in the severity of clinical presentations with the highest mortality in the general population attributed to DENV and neurological morbidity due to ZIKV. ZIKV and DENV infections can cause fetal los...
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
by Robert C. Reiner Jr., Steven T. Stoddard, Gonzalo M. Vazquez-Prokopec, Helvio Astete, T. Alex Perkins, Moises Sihuincha, Jeffrey D. Stancil, David L. Smith, Tadeuz J. Kochel, Eric S. Halsey, Uriel Kitron, Amy C. Morrison, Thomas W. Scott During the last 50 years, the geographic range of the mosquitoAedes aegypti has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue. There is a growing consensus that vector control is essential to preventAedes-borne diseases, even as effective vaccines become available. What remains uncl...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This study reveals an unexpected reciprocal role of a cellular receptor tyrosine kinase regulating DENV RNA replication and the production of infectious virions.Graphical Abstract
Source: Cell Reports - Category: Cytology Source Type: research
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