Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement [Pharmacology]

G protein-coupled receptors (GPCRs) are key biological switches that transmit both internal and external stimuli into the cell interior. Among the GPCRs, the “light receptor” rhodopsin has been shown to activate with a rearrangement of the transmembrane (TM) helix bundle within ∼1 ms, while all other receptors are thought to...

Source: Proceedings of the National Academy of Sciences - May 13, 2019 Category: Science Authors: Eugene O. Grushevskyi, Taulant Kukaj, Ralf Schmauder, Andreas Bock, Ulrike Zabel, Tina Schwabe, Klaus Benndorf, Martin J. Lohse Tags: Biological Sciences Source Type: research