Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis [Neuroscience]

Regional differences in neurons, astrocytes, oligodendrocytes, and microglia exist in the brain during health, and regional differences in the transcriptome may occur for each cell type during neurodegeneration. Multiple sclerosis (MS) is multifocal, and regional differences in the astrocyte transcriptome occur in experimental autoimmune encephalomyelitis (EAE), an MS model. MS...

Source: Proceedings of the National Academy of Sciences - May 13, 2019 Category: Science Authors: Rhonda R. Voskuhl, Noriko Itoh, Alessia Tassoni, Macy Akiyo Matsukawa, Emily Ren, Vincent Tse, Ellis Jang, Timothy Takazo Suen, Yuichiro Itoh Tags: PNAS Plus Source Type: research