IJERPH, Vol. 16, Pages 1698: Assessment of Groundwater Quality in CKDu Affected Areas of Sri Lanka: Implications for Drinking Water Treatment

This study investigated the water quality of the groundwater that was collected from the chronic kidney disease of unknown etiology (CKDu) prevailing areas in the dry zone of Sri Lanka to assess its suitability for drinking purposes, and for the first time a Water Quality Index (WQI) with emphasis on proposing appropriate drinking water treatment method was developed. A total of 88 groundwater samples were collected in dry (December 2016) and wet (May 2017) seasons; high concentrations of water hardness, fluoride, salinity, dissolved organic carbon (DOC), and the general alkaline nature of water were the main issues that were observed for disease incidence. The chemical weathering of the underlying bedrock, followed by ion exchange and precipitation processes, primarily controlled groundwater geochemistry. During the 1985–2017 period, the variations of the annual rainfall and temperature were minimal, which suggests no evidence for major climatic changes within the study areas. Almost all of the samples from the CKDu regions show a low alkali hazard and most of the samples show a medium to high salinity hazard. The DOC of the studied samples was mainly composed of the organic fractions in the following order, as fulvic acids > humic acids > aromatic protein II > soluble microbial by-products, and the molecular weights (MW) of these fractions ranged from 100–3000 Da. Based on the water quality index (WQI) calculations, it was found that...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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Publication date: Available online 25 May 2019Source: Canadian Journal of CardiologyAuthor(s): Rebecca Rodin, Christopher T. ChanAbstractChronic kidney disease (CKD) is associated with premature cardiovascular morbidity and mortality. Traditional Framingham risk factors contribute partially to the malignant form of cardiovascular disease (CVD) in CKD. Uremic specific risk factors including: chronic inflammation, retention of uremic toxins and abnormal bone mineral metabolism have independently been linked to the pathogenesis of premature vascular aging, atherosclerosis, and CVD. This review will explore the mechanisms by w...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Authors: Chillo P, Ismail A, Sanyiwa A, Ruggajo P, Kamuhabwa A Abstract Background: Hypertensive retinopathy is a known marker of cardiovascular disease, and among unselected patients with chronic kidney disease (CKD) more severe retinopathy has been associated with lower estimated glomerular filtration rate (eGFR). This association has, however, not been widely studied among nondiabetic hypertensive patients with CKD, especially in sub-Saharan Africa. We aimed to determine the prevalence and severity of hypertensive retinopathy and its relationship with eGFR among nondiabetic CKD patients seen at Muhimbili Nationa...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
ConclusionsPatients in intermediate stages do not receive follow-up with a multidisciplinary team at the recommended frequency. The preventive approach of the progression of renal disease in the intermediate stage in the studied municipality was not within the recommendations of the Ministry of Health.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
There are three reasons to generate a new human kidney. The first is to learn more about the biology of the developing and mature organ. The second is to generate tissues with which to model congenital and acquired kidney diseases. In particular, growing human kidneys in this manner should ultimately help to understand the mechanisms of common chronic kidney diseases such as diabetic nephropathy and others featuring fibrosis, as well as nephrotoxicity. The third is to provide functional kidney tissues that can be directly used in regenerative medicine therapies.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Review Source Type: research
Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1...
Source: Cytotherapy - Category: Cytology Source Type: research
Condition:   Hepatitis B Vaccine Interventions:   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6;   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6;   Biological: 60 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6 Sponsors:   Shanxi Medical University;   Centers for Disease Control and Prevention, China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributors : Blue B Lake ; Song Chen ; Masato Hoshi ; Nongluk Plongthongkum ; Kun Zhang ; Sanjay JainSeries Type : Expression profiling by high throughput sequencingOrganism :Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (snDrop-Seq) that we use to resolve thirty distinct cell populations in human adult kidney. We define molecular transition states along more than ten nephron segments spanning two major kidney region...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
CONCLUSIONS: YF acute severe cases show a generalised involvement of different organs (liver, spleen, heart, kidneys, intestines and pancreas), and different parameters were related to outcome. Factor V and lipase are independent variables associated with death, reinforcing the importance of hemorrhagic events due to fulminant liver failure and pointing to pancreatitis as a relevant event in the outcome of the disease. PMID: 31116245 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
Authors: Herrera-Añazco P, Atamari-Anahui N, Flores-Benites V Abstract We conducted a descriptive and ecological study that evaluated the relationship between the prevalence trend of patients with chronic kidney disease (CKD), the number of nephrologists, and the number of hemodialysis services of the Ministry of Health (MINSA). The study was based on a secondary analysis of the care provided by MINSA, the Observatory of Human Resources in Health, and the hemodialysis services registered as Health Service Providers of the Intangible Health Solidarity Fund (FISSAL, in Spanish). The adjusted prevalence of CKD ...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
In this study, the relationship between HDL-C variability and the risk for progression to end-stage renal disease (ESRD) was investigated.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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