Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery

AbstractBackgroundMorbid obesity is a worldwide epidemic and is increasingly treated by bariatric surgery. Fatty liver is a common finding; almost half of all patients with non-alcoholic steatohepatitis develop steatohepatitis. Bariatric surgery improves steatohepatitis documented by liver biopsy and single voxel magnetic resonance imaging (MRI) techniques.ObjectiveTo investigate changes before and after bariatric surgery using whole organ MRI quantification of liver, visceral, and subcutaneous fat.SettingUniversity of Basel Hospital and St. Clara Research Ltd, Basel, Switzerland.MethodsSixteen morbidly obese patients were evaluated by abdominal MRI-scanning before and 3, 6, 12, and 24  months after bariatric surgery to measure percentage liver fat (%-LF), total liver volume (TLV) and visceral and subcutaneous adipose tissues (VAT and SAT). Fasting plasma samples were taken for measurement of glucose, insulin, blood lipids, and liver biomarkers. In a control group of 12 healthy l ean volunteers, the liver biomarker was also measured.ResultsThe reproducibility of fat quantification by use of MRI was excellent. LF decreased significantly faster than VAT and SAT (%-LF vs. VATp 
Source: Obesity Surgery - Category: Surgery Source Type: research

Related Links:

Publication date: Available online 23 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): V. Arroyo-Jousse, A. Jaramillo, E. Castaño-Moreno, M. Lépez, K. Carrasco-Negüe, P. CasanelloAbstractMaternal pregestational obesity is a well-known risk factor for offspring obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes. The mechanisms by which maternal obesity can induce alterations in fetal and later neonatal metabolism are not fully elucidated due to its complexity and multifactorial causes. Two adipokines, leptin and adiponectin, are involved i...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01858A, CommunicationJulie E. Laudenschlager, Logan A. Combee, Michael K. Hilinski Sc(OTf)3-promoted [5 + 1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Publication date: Available online 23 October 2019Source: Life SciencesAuthor(s): Qi Li, Xinglan An, Xiaxia Man, Meiran Chu, Tianchuang Zhao, Hao Yu, Ziyi LiAbstractAimsThe present study aimed to investigate the effects of cyclophosphamide (Cytoxan, CTX) on premature ovarian failure (POF) in mice and its regulatory mechanisms by transcriptome analysis.Main methodsFemale C57BL/6 mice were treated with a single intraperitoneal injection of 70 mg/kg CTX. Serum levels of estradiol (E2) and follicle stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay (ELISA), and follicular structure differences were ob...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Life SciencesAuthor(s): Pollyana S. Siqueira-Lima, Jullyana S.S. Quintans, Luana Heimfarth, Fabiolla R.S. Passos, Erik W.M. Pereira, Marilia M. Rezende, José E.R. Menezes-Filho, Rosana S.S. Barreto, Henrique D.M. Coutinho, Adriano A.S. Araújo, Aline S. Medrado, Ligia A. Naves, Horácio F. Bomfim, Angélica M. Lucchese, Sathiyabama Rajiv Gandhi, Lucindo J. Quintans-JúniorAbstractNeuropathic pain (NP) is a difficult condition to treat because of the modest efficacy of available drugs. New treatments are required. In the study we aimed ...
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSION: Cholesterol overloads not only trigger hepatic damage, but also affect the gallbladder significantly. PMID: 31104801 [PubMed - in process]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Ali Mahzari1, Songpei Li1, Xiu Zhou1,2, Dongli Li2, Sherouk Fouda1, Majid Alhomrani1, Wala Alzahrani1, Stephen R. Robinson1 and Ji-Ming Ye1,2* 1Lipid Biology and Metabolic Disease Laboratory, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia 2School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and the mechanism involved. The study was performed in C57B/6J mice fed a MCD diet for 6 weeks to induce NAS...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Cholesterol overloads not only trigger hepatic damage, but also affect the gallbladder significantly. PMID: 30145572 [PubMed - in process]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
The globally rising obesity epidemic is associated with a broad spectrum of diseases including atherosclerosis and non-alcoholic fatty liver (NAFL) disease. In the past, research focused on the vasculature or ...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
Non-alcoholic fatty liver disease (NAFLD) parallels the obesity epidemic and associates with components of the metabolic syndrome (MetS). Cholesterol efflux capacity (CEC) represents a key metric of high density lipoprotein (HDL) function which may predict atherosclerotic cardiovascular disease (CVD). Here we interrogated the relationship of CEC with NAFLD.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Conclusion: Our data warrant the future evaluation of NAD+ boosting strategies to manage the development or progression of NAFLD. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
More News: Alcoholism | Bariatric Surgery | Cholesterol | Eating Disorders & Weight Management | Epidemics | Epidemiology | Fatty Liver Disease (FLD) | Insulin | Liver | MRI Scan | Obesity | PET Scan | Surgery | Switzerland Health | Urology & Nephrology