Efficacy and safety of the dual bronchodilator combination umeclidinium/vilanterol in COPD by age and airflow limitation severity: A pooled post hoc analysis of seven clinical trials

This study compared the efficacy and safety of a long-acting muscarinic antagonist/long-acting β2-agonist dry powder combination in elderly patients with COPD and patients with moderate-to-very severe airflow limitation.MethodsThis post hoc pooled analysis of seven randomized studies of ≥12 weeks’ duration investigated the efficacy and safety of umeclidinium/vilanterol (UMEC/VI) 62.5/25 μg versus tiotropium (TIO) 18 μg or fluticasone propionate/salmeterol (FP/SAL) 250/50 μg. Change from baseline in trough forced expiratory volume in 1 s (FEV1), a common efficacy measure in all trials, proportion of FEV1 responders (≥100 mL increase from baseline) and safety outcomes were analyzed at Day 28, 56, and 84 in patients classified by age (
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Conclusion: Neuropsychiatric illness increased odds of being frail on a predominantly physical/motoric measure, but only when symptomatic. Lack of association with asymptomatic impairment may reflect the importance of functional limitation to frailty, or possibly a unique resilience phenotype. Understanding why sex and symptomatic neuropsychiatric illness are associated with frailty will be important in managing HIV-associated morbidity in aging populations.
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
(American Thoracic Society) David Geoffrey Chapman, BSc, PhD, of University of Technology in Sydney, Australia, has been awarded the new ATS Foundation/ResMed Research Fellowship in Sleep-disordered Breathing and PAP Therapy.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
npj Primary Care Respiratory Medicine, Published online: 15 July 2019; doi:10.1038/s41533-019-0138-6Incidence of type II diabetes in chronic obstructive pulmonary disease: a nested case–control study
Source: npj Primary Care Respiratory Medicine - Category: Primary Care Authors: Source Type: research
CONCLUSIONS: Despite major therapeutic progress, the essential problems of COPD management remain. While the treatment armamentarium has expanded in recent years, there is still a great deal of work to be done in simplifying treatment regimens, improving the administration of these treatments and motivating patients to be compliant with them. This review also highlights the need for better physician-patient communication. PMID: 31300244 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Authors: Olschewski H, Canepa M, Kovacs G Abstract Chronic heart and lung diseases are very common in the elderly population. The combination of chronic heart failure and chronic obstructive pulmonary disease (COPD) is also common and, according to current guidelines, these patients should be treated for both diseases. In patients with heart failure, beta-blockers are very important drugs because their use is associated with significantly improved morbidity and mortality. These beneficial effects were documented in patients with and without COPD, although theoretically there is a risk for bronchoconstriction, parti...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
This study investigated whether dietary patterns were associated with post-bronchodilator airway obstruction, a hallmark of COPD, in dairy farmers exposed to organic dusts. All subjects were identified by screening programs and patients with airflow obstruction were matched with subjects with normal spirometry. Six groups were compared, defined by their exposures (non-smoking dairy farmers, smokers ≥ 10 pack-years with no occupational exposure, and smoking dairy farmers) and the presence or absence of post-bronchodilator airflow obstruction, resulting in 321 study subjects. The Alternative Healthy Eating Index (AHEI) sc...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Authors: Odackal J, Lyons G, Harris D Abstract One in four patients with chronic obstructive pulmonary disease (COPD) has depression. However, the effect of depressive symptoms on self-reported physical function among patients with COPD is not fully defined. We tested the hypothesis that depressive symptoms among patients with COPD are associated with increased self-reporting of physical limitations in a nationally representative sample of adults living in the USA. We sampled 775 adults with obstructive lung disease and history of regular smoking from 2007 to 2012 National Health and Nutrition Examination Survey (N...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Anarticle published recently by the American Lung Association claims that vaping causes popcorn lung and COPD. There is no evidence to support either of these assertions. In fact, I'm not aware of a single case of either popcorn lung or COPD that has ever been diagnosed in a vaper without a history of cigarette smoking. Even active smoking itself is not associated with popcorn lung, and cigarette smoke contains about 750 times the amount of diacetyl (the putative cause of popcorn lung) than e-cigarette aerosol. So the American Lung Association is lying about the health risks of vaping.The Rest of the StoryHowever, that's n...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
No abstract available
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research
Conclusions:Persons with OVS have significantly lower levels of PA and higher levels of inflammatory biomarkers, compared to COPD alone. Lower PA is significantly associated with higher IL-6 levels in OVS.Citation:Fitzgibbons CM, Goldstein RL, Gottlieb DJ, Moy ML. Physical activity in overlap syndrome of COPD and obstructive sleep apnea: relationship with markers of systemic inflammation.J Clin Sleep Med. 2019;15(7):973–978.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
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