Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment

Publication date: July 2019Source: Journal of Functional Foods, Volume 58Author(s): Sunggun Kim, Soo Jeong Kim, Eun-Sang Jo, Kicheol Gil, Na-Yeon Kim, Ji Sung Park, Dongbok Park, So-Young Park, Kwang Woo HwangAbstractWe aimed to investigate possible anticancer effects of Amtak-ssamchae (a newly bred cabbage line containing more carotenoids) in an in vitro pancreatic-tumor cell model and an in vivo model (Panc02 cells). In an in vitro assay, Amtak-ssamchae significantly reduced the viability of Panc02 cells relative to normal ssamchae. Furthermore, an Amtak-ssamchae extract significantly reduced the tumor size in mice inoculated with Panc02 cells, and this effect was accompanied by changes in the cell population in/near the tumor and spleen. Treatment with the extract of the new cabbage line blocked regulatory-T-cell recruitment, which is known as the main pathological mechanism of action of pancreatic cancer to avoid host immunity. Additionally, Amtak-ssamchae (not the normal line) contained β-carotene (at 27.9 ± 2.1 μg/g). Thus, we suggest that the Amtak-ssamchae extract could be a resource for natural supplements and functional foods for combating pancreatic cancer.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research