A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis

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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research

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PMID: 31205110 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
CONCLUSIONS: The varied pharmacologic mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacologic effects await further study. PMID: 31205106 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
This study provides novel insight into genetic determinants of poor outcomes after acute injury to the neonatal brain and how early-life brain injury can influence adult-onset neurodegenerative disease during aging.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
Abstract Routine quantitative electromyography is used for the assessment of the presence of lower motor neurone involvement and its consequences, including primary denervation and compensatory reinnervation of muscle fibres. However, it is not useful for the assessment of the motor unit number reserve. The need for a valid biomarker to evaluate lower motor neurone disease progression in such diseases as amyotrophic lateral sclerosis, and for use in clinical trials, has led to a number of studies of the methods that allow assessment of the number of motor units. In this review, motor unit number estimation (MUNE) ...
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Tags: Neurol Neurochir Pol Source Type: research
Authors: Goutman SA, Savelieff MG, Sakowski SA, Feldman EL Abstract Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of cortical, brainstem, and spinal motor neurons; it causes progressive muscle weakness and atrophy, respiratory failure, and death. No currently available treatment either stops or reverses this disease. Therapeutics to slow, stop, and reverse ALS are needed. Stem cells may be a viable solution to sustain and nurture diseased motor neurons. Several early-stage clinical trials have been launched to assess the potential of stem cells for ALS treatment. Areas covered: Th...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
This study aimed to conduct a meta-analysis of the association between the C allele of rs12608932, a single-nucleotide polymorphism located in an intron ofUNC13A, and risk of ALS and patient survival.MethodsPubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases were systematically searched for genome-wide association studies or case-control studies published up to January 2019 on the association between this variant inUNC13A and risk and/or prognosis of ALS. Data from eligible studies were extracted and analyzed.ResultsThe pooled data (28,072 patients with sporadic ALS and...
Source: Neurological Sciences - Category: Neurology Source Type: research
The objective of this study is to summarize the experimental procedures of previous studies and provide a guide for researchers interested in this field. In this work the basic characteristics of EOGs, associated measurements, and signal processing and pattern recognition algorithms are briefly reviewed, and various applications reported in the existing literature are listed. It is expected that EOGs will be a useful source of communication in virtual reality environments, and can act as a valuable communication tools for people with amyotrophic lateral sclerosis.
Source: Sensors - Category: Biotechnology Authors: Tags: Review Source Type: research
Contributors : Riccardo De Santis ; Vincenzo Alfano ; Valeria de Turris ; Alessio Colantoni ; Laura Santini ; Maria G Garone ; Giuseppe Antonacci ; Giovanna Peruzzi ; Emma Sudria-Lopez ; Emanuel Wyler ; Markus Landthaler ; R J Pasterkamp ; Irene Bozzoni ; Alessandro RosaSeries Type : OtherOrganism : Homo sapiensDetermination of RNAs bound by wildtype and P525L mutant FUS in human iPSC-derived motoneurons using PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation)
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Synaptic abnormalities, perturbed endosomal recycling mediated by loss of the small GTPase RAB11, and neuroinflammatory signaling have been associated with multiple neurodegenerative diseases including the mot...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Micro report Source Type: research
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