Inhibition of CBP/ β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells

ConclusionsTargeting Porcupine or the CBP/ β-catenin interaction seems to be an effective strategy for the inhibition of canonical Wnt signaling in HNSCC cells. Further studies are required to confirm the possible therapeutic effect of IWP-2 and PRI-724 in HNSCC.

http://link.springer.com/10.1007/s13402-019-00440-4

Source: Cellular Oncology - May 13, 2019 Category: Cancer & Oncology Source Type: research