Clinical benefit, toxicity and cost of metastatic breast cancer therapies: systematic review and meta-analysis

ConclusionsIn this era of increasing choices of MBC therapeutic agents and no superior approach to choosing a treatment regimen, the ability to compare multiple therapies based on survival, toxicity and cost would enable treating physicians to optimize therapeutic choices for patients. For investigators, it can point them in research directions that were previously non-obvious and for guideline designers, enable them to efficiently review the MBC clinical trial literature and visualize how regimens compare in the key dimensions of clinical benefit, toxicity, and cost.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research

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AbstractIn the present study, a novel series of quinazoline derivatives is developed for cancer therapy. All the synthesised analogues were evaluated against a panel of 60 human cancer cell lines for the antiproliferative activity. Significant and selective growth inhibition of several solid tumour cell lines such as NCI-H322M, NCI-H522 (non-small cell lung cancer), IGROV1, SK-OV-3 (ovarian cancer), TK-10 (renal cancer) and MDA-MB-468 (breast cancer) was observed. Further, all the new amide analogues strongly inhibited EGFR in low nanomolar range with morpholino quinazoline10 producing activity (IC50 = 6.12&t...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
Practice-changing data suggest de-escalation of treatment in breast cancer, but are they relevant to minority patients who are'grossly underrepresented'in clinical trials?Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
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Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
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Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
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Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
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Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS A: Lifestyle, Prevention including Secondary Prevention Source Type: research
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Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS A: Lifestyle, Prevention including Secondary Prevention Source Type: research
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Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTER IN THE SPOTLIGHT: Poster in the Spotlight II Source Type: research
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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