Suicidality and risk of suicidality in psoriasis: a critical appraisal of two systematic reviews and meta-analyses - Matterne U, Baumeister SE, Apfelbacher C.

AIM: Chi et  al. (Am J Clin Dermatol; 31(5): 798-807) and Singh et al (J Am Acad Dermatol; 77(3): 425-440.e2) each conducted a systematic review and meta-analysis of observational studies examining the relationship between suicidality and psoriasis. SETTI...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

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A report in the June 2019 issue of the Journal of Investigative Dermatology reveals a role of neutrophil extracellular traps (NETs) in the induction of T helper type 17 cell responses and shows the relevance of this pathway in patients with psoriasis carrying a common risk variant in the TRAF3IP2 gene (Lambert et  al., 2019). This work provides a new piece to the puzzle that links neutrophils to the T helper type 17–mediated pathogenesis of psoriasis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
Observational epidemiological studies have identified associations between a number of modifiable exposures and outcomes, including in dermatology, such as between smoking and psoriasis. However, it is challenging to determine if such relationships are causal because of the potential of confounding and reverse causation. Mendelian randomization (MR) is a statistical method that can be used to investigate the causal relationships between an exposure and outcome by using a genetic instrument that proxies the exposure.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Research Techniques Made Simple Source Type: research
Authors: Johar A, Thevarajah S, Heng A, Chan LC, Ch'ng CC, Mohd Safdar NA, Muniandy P, Taib T, Tan WC, Tey KE Abstract Psoriasis is a chronic inflammatory skin disease affecting nearly 10% of dermatologic patients in Malaysia. Treatment options include topical agents and phototherapy as well as nonbiologic and biologic systemic therapy. Mild psoriasis can often be managed with topical agents. However, managing moderate to severe psoriasis is more challenging and may require systemic treatment with nonbiologics or biologics. Despite the availability of several biologics, there are many unmet clinical needs, which ma...
Source: Dermatology Research and Practice - Category: Dermatology Tags: Dermatol Res Pract Source Type: research
Psoriasis is a multifactorial disease with a dysregulation in immune system. The aim of this study was to survey the clinical efficacy and safety of muramyl peptide - the ligand of the receptors of innate immunity (drug Licopid®, AO Peptek, Moscow, Russia) in patients with psoriasis. The effect of muramyl peptide on 86 patients with different severity of plaque psoriasis was tested. The Psoriasis Area and Severity Index (PASI), cytokine status and production of nitric oxide in blood serum, and the subsequent course of psoriasis have been evaluated. Evaluation of significance of observed differences was presented by the...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Several lines of evidence indicate that the immune system, inflammation and coagulation are simultaneously activated in autoimmune and immune-mediated skin diseases. Proinflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha induce the expression of the main initiator of coagulation, i.e. tissue factor. The proteases of coagulation in turn act on protease-activated receptors inducing the expression of various proinflammatory cytokines triggering inflammation. The cross-talk among immune system, inflammation and coagulation amplifies and maintains the activation of all three pathways. This review focuse...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractConsidered more efficacious and safer than traditional systemic drugs, biologic therapies have dramatically improved the quality of life of patients with psoriasis. Recently, there has been a proliferation of new targeted treatment options, including anti-interleukin-17, anti-interleukin-12/23, as well as small-molecule drugs such as apremilast. There are nevertheless some concerns regarding their use, especially in patients with chronic infections such as hepatitis B virus (HBV) and hepatitis C virus (HCV). It has been estimated that two billion individuals are infected with HBV worldwide and approximately 240 mil...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Conditions:   Nail Psoriasis;   Nail Diseases Interventions:   Drug: Placebos;   Drug: Triamcinolone Acetonide 2.5 mg/mL;   Drug: Triamcinolone Acetonide 5.0 mg/mL;   Drug: Triamcinolone Acetonide 7.5 mg/mL;   Drug: Triamcinolone Acetonide 10 mg/mL Sponsor:   Weill Medical College of Cornell University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A new review examines the similarities and differences between these conditions, and explores the implications for treatment.Current Opinion in Rheumatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
A number of studies have shown the relationship between the pathogenesis of psoriasis and skin resident memory T (TRM) cells.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
TUESDAY, June 18, 2019 -- Abdominal obesity may increase the risk for psoriasis, according to a study published online May 31 in the Journal of Dermatology. Ju Hee Han, M.D., from the Seoul St. Mary's Hospital in South Korea, and colleagues used...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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