Lipid and glucose metabolism during the menopausal transition & beyond

Transition to menopause, characterized by estrogen decline, is associated with increase in body weight and central adiposity. Moreover, energy expenditure is decreased, as a result of mood changes, comorbidity and inactivity. Insulin secretion and action may also be affected. All these metabolic alterations increase the risk of Type 2 diabetes mellitus. LDL-cholesterol and triglyceride levels increase, while HDL-cholesterol levels decrease during the transition to menopause. Oral estrogens have a decreasing effect on LDL-cholesterol, however, they may increase triglyceride levels.
Source: Maturitas - Category: Primary Care Authors: Tags: INV7 Source Type: research