HRT for young women with premature ovarian insufficiency

Premature ovarian insufficiency (POI) is a condition characterized by sex-steroid deficiency, amenorrhea, infertility and elevated gonadotropins in women younger than 40 years of age. Women with POI need exogenous sex steroids to compensate for the decreased production by their ovaries and for these young women hormone replacement therapy is “true replacement” of ovarian hormones. Optimal hormone therapy depends on whether the patient has primary or secondary amenorrhea. Young women with primary amenorrhea in whom secondary sex characteristics have failed to develop initially should be given very low doses of estrogen in an attempt to mimic the gradual pubertal maturation process.
Source: Maturitas - Category: Primary Care Authors: Tags: INV48 Source Type: research