Longterm consequences of the WHI on public health issues and quality of life

The unexpected early termination of the WHI Trial of conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) in mid-2002 triggered a rapid and dramatic decline in the use of MHT worldwide. This effect was primarily due to fears of increased risks for breast cancer and coronary heart disease purportedly seen in the cohort overall - aged 50 to 79 on randomization (mean 63 years and 12 years postmenopausal); a cohort comprised primarily of women much older than those who would typically be started on MHT in clinical practice.
Source: Maturitas - Category: Primary Care Authors: Tags: INV49 Source Type: research