Comparative analysis of the histopathological and epidemiological profile of ductal and lobular breast carcinomas diagnosed at the Hospital de Clínicas da Universidade Federal do Paraná during the period 2008-2013

Conclusion: The breast carcinomas evaluated in this study presented a profile similar to that reported in the literature, with some peculiarities inherent to the local pathology service. Nevertheless, the low frequency of in situ cases indicates failure in early diagnosis.RESUMEN Introducci ón: El cáncer de mama es la segunda causa de muerte por cáncer entre mujeres alrededor del mundo, y estudios epidemiológicospueden contribuir al entendimiento de sus mecanismos. Objetivos: Determinar el número de casos de carcinoma de mama diagnosticados en un período de seis anos. Método: El perfil de los carcinomas de mama diagnosticados en un hospital terciario de Curitiba ha sido comparado con aquel de la literatura, a través de análisis retrospectivo de historias de carcinoma de mama ductal/tipos especialesy lobulillar de pacientes atendidos entre los anos de 2008y 2013. Resul tados: Se han diagnosticado 327 (91,6%) casos de carcinoma ductal/tipos especiales y 30 (8,4%) de carcinoma lobulillar, totalizando 357 muestras. De estos casos, 27 (7,5%) eran de carcinoma in situ (20 ductaly siete lobulillar) y 330 (92,4%), invasores (307 ductal invasor +tipos especialesy 23 lobul illar). La incidencia de tumores de mama en mujeres fue de 99,1%, siendo los pacientes, en su generalidad, mayores de50 anos (67,2%). Con respecto a la estadificación de Unión Internacional Contra el Cáncer/American Joint Committee on...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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Re: Yang CJ, Kumar A, Gulack BC, Mulvihill MS, Hartwig MG, Wang X, et  al. Long-term outcomes after lobectomy for non–small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis. J Thoracic Cardiovasc Surg. 2016;151:1380-8.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Notice of Correction Source Type: research
Analyst, 2019, Advance Article DOI: 10.1039/C9AN00691E, PaperBo Yin, Sha Sha Li, Shao Hua Lu, Jia Ying Mi, Hong Lin Zhai The feature information was extracted from the 3D spectrum by the TM method, and the simultaneous quantification of intracellular thiols was realized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
AbstractA novel series of coumarin-pyridine/fused pyridine hybrids were designed and synthesized. Their anticancer activity was evaluated against human cancer cell lines MCF-7, HCT-116, HepG-2, and A549. Compounds9,10, and11 showed the most potent growth inhibitory activities with IC50 values ranging from 1.1 to 2.4  μM, against MCF-7 cell line. Flow cytometric analysis revealed that these compounds induced cell cycle arrest in the G2/M phase followed by apoptotic cell death. Consistent with these results, the activity of caspase-3 in MCF-7 cells was tested. The results indicated that compounds9,10, and11 increas...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
(Medical College of Georgia at Augusta University) A checkpoint may delay travelers but it can help give cancer free rein by suppressing the natural immune response that should destroy it, researchers say.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Conclusions: In this cohort of women with elevated risk, high serum 25(OH)D levels and regular vitamin D supplement use were associated with lower rates of incident, postmenopausal breast cancer over 5 y of follow-up. These results may help to establish clinical benchmarks for 25(OH)D levels; in addition, they support the hypothesis that vitamin D supplementation is useful in breast cancer prevention. https://doi.org/10.1289/EHP943 About This Article Received: 09 August 2016 Revised: 23 January 2017 Accepted: 06 February 2017 Published: 06 July 2017 Address correspondence to C. R. Weinberg, 111 TW Alexander Dr., Rese...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Mixed ductal-lobular carcinomas (MDL) display both ductal and lobular morphology, and are a clear example of intratumour morphological heterogeneity. The evolution of MDL carcinomas is not well understood. There is a paucity of data surrounding the genetic origin of the different morphological compartments and it remains to be seen whether the coincident presentation of these distinct morphological entities represents two independent tumours that have collided (so called 'collision tumours'), or whether they arise from a common clone. We propose that clonal progression during the evolution of these tumours is associated wi...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
Authors: Provencher L, Hogue JC, Desbiens C, Poirier B, Poirier E, Boudreau D, Joyal M, Diorio C, Duchesne N, Chiquette J Abstract BACKGROUND: Screening clinical breast examination (cbe) is controversial; the use of cbe is declining not only as a screening tool, but also as a diagnostic tool. In the present study, we aimed to assess the value of cbe in breast cancer detection in a tertiary care centre for breast diseases. METHODS: This retrospective study of all breast cancers diagnosed between July 1999 and December 2010 at our centre categorized cases according to the mean of detection (cbe, mammography, or b...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
ConclusionPLCIS is an uncommon in situ carcinoma presenting via mammographic and also in the symptomatic setting. Unlike classical LCIS, PLCIS is a disease of postmenopausal women. It is multifocal in approximately one fifth of the cases.PLCIS is commonly associated with classical LCIS and both ILC and IPLC. When identified in core biopsy, the upgrade rate in this series was 30.4% which increased to 50% if the lesion co-existed with DCIS. The associated cancers are often ER positive, HER2 negative. These findings support managing those lesions surgically as per DCIS.Citation Format: Shaaban AM, Smith S, Bradley S, McMahon ...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
Authors: Fernandes A, Bianchi G, Feltri AP, Pérez M, Correnti M Abstract Breast cancer accounts for 16% of all female cancers worldwide, and in Venezuela, it is the leading cause of death among women. Recently, the presence of high-risk genotypes of human papillomavirus (HPV) has been demonstrated in breast cancer and has been associated with histopathological features of the tumours. In Venezuela, there is no study which determines the association between the presence of HPV in breast cancer and the histopathological features. The aim of this investigation is to evaluate the presence of HPV in the different...
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
Conclusion: The successful treatment of breast cancer is based on several variables including type of cancer, grade, size at diagnosis, and stage at diagnosis. We do not know at what point these lesions diagnosed with screening breast usg would have been clinically evident, either on mammography or physical examination. One might consider that the treatment outcome would be altered if the lesions were larger and with more positive lymph nodes. Citation Format: Jean M Weigert. An analysis of lesions diagnosed on screening breast ultrasound in women with dense breasts: Four years of data [abstract]. In: Proceedings of the Th...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
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