Long-term consequences of Zika virus infection

(Society for Neuroscience) Mice exposed to the Zika virus during later stages of gestation present behaviors reminiscent of attention-deficit/hyperactivity disorder, according to a study of genetically diverse animals. The findings, published in JNeurosci, suggest children exposed to the virus during the 2015-16 epidemic may harbor increased risk for developmental disorders.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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AbstractUsing high-throughput sequencing of small interfering RNAs (siRNAs), virion-associated nucleic acid (VANA), and double stranded RNAs (dsRNAs), we have determined the complete genome sequences of Comorian isolates of two ipomoviruses, cassava brown streak virus (CBSV) and a divergent isolate of Ugandan cassava brown streak virus (UCBSV-KM) representing a new strain of this virus. While the large ORF of CBSV shares the highest nucleotide sequence identity (95.9%) with a Tanzanian isolate of CBSV, the large UCBSV-KM ORF shares the highest nucleotide sequence identity (77.5%) with a Malawian isolate of UCBSV. This low ...
Source: Archives of Virology - Category: Virology Source Type: research
The University of Pittsburgh's Division of General Internal Medicine has received a $5.8 million grant from the National Institutes of Health to conduct opioid research in Appalachia, the school announced Monday morning. Dr. Jane Liebschutz will establish the Appalachian Node of the National Institute on Drug Abuse Clinical Trials Network to facilitate research in the region, which has been badly affected by the opioid epidemic. "Historical and cultural factors have caused Appalachia to experience…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
This study explored t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The current study examines associations between reactive and proactive aggression and suicidal thoughts and behaviors among youth (N  = 115, 62% male), ranging from 6 to 12 years, seeking services in an outpatient psychological clinic. Symptoms of hypera...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Discussion Transplantation is not a common problem for primary care physicians but when a child’s disease has progressed to end-stage organ failure, transplantation can be the only treatment available. While the primary care provider usually is not involved in the daily management of patients before, during and after transplantation, they can be involved in many areas. These can include providing appropriate primary and acute care, ordering and obtaining necessary medical tests, medications and equipment, assisting with medical insurance, providing medical history and records to consultants, translating medical infor...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
In this study, among a total of 3,531 trapped rodents dominated byApodemus agrarius (59.7%), 330Leptospira strains were successfully isolated from six different sites in Jiangxi between 2002 and 2015. Adding 71 local strains from humans, various kinds of livestock and wild animals in Jiangxi, a total of 401 epidemic strains were characterized using 16S rRNA gene senquencing, multilocus sequence typing (MLST) and the microscopic agglutination test (MAT). Among them, the most prevalent serogroup was Icterohaemorrhagiae (61.10%), followed by Javanica (19.20%) and Australis (9.73%); the remaining five serogroups, Canicola, Aut...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Nature, Published online: 24 June 2019; doi:10.1038/d41586-019-01949-2A molecular dialogue between neurons and star-shaped cells called astrocytes in the striatum of the mouse brain leads to behavioural hyperactivity and inattentiveness that are reminiscent of attention-deficit hyperactivity disorder.
Source: Nature AOP - Category: Research Authors: Source Type: research
Authors: Holdorff B Abstract In his Thèse de Paris (1919) Konstantin Tretiakoff (1892-1956) described the two main morphological lesions in Parkinson's disease: the loss of pigmented nerve cells in the Substantia nigra and the intracellular inclusion bodies in idiopathic paralysis agitans, calling them "Corps de Lewy," which already had been described by F. H. Lewy in 1912. Tretiakoff's findings on idiopathic Parkinson's disease were confirmed years later by Rolf Hassler in his dissertation on anatomy and pathology of Substantia nigra in Berlin (1938, 1939). German authors in the 1920s underestimat...
Source: Journal of the History of the Neurosciences - Category: Neuroscience Tags: J Hist Neurosci Source Type: research
Publication date: Available online 21 June 2019Source: The Lancet HIVAuthor(s): The Lancet HIV
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Abstract OBJECTIVES: To describe the impact of central nervous system-directed treatment on attention and its relation to academic outcomes in childhood acute lymphoblastic leukemia (ALL) survivors. SAMPLE & SETTING: 51 children diagnosed with ALL at two pediatric oncology treatment centers in the southwestern United States. METHODS & VARIABLES: A prospective, longitudinal design measured attention after a child was in remission, two years after the start of treatment, and at the end of treatment. Attention measures from the Conners' Continuous Performance Test were grouped into composite subdoma...
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
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