Role of HGF for reprogramming human liver progenitor cells: Non-essential but stimulative supplement

With great interest, we read the article written by Kim et al. in a recent issue of Journal of Hepatology.1 The authors developed a successful HAC culture system for reprogramming mature human hepatocytes into bipotential progenitor cells treated with 2 small molecules A83-01 and CHIR99021 (AC) in combination with hepatocyte growth factor (HGF). Their chemically derived human hepatocyte progenitors could sustain themselves as a population of progenitor cells over a long period while maintaining chromosomal stability and the capacity to differentiate into functional hepatocytes and biliary epithelial cells in vitro and in vivo.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research