John Tesser, MD, FACP, FACR - Overcoming Challenges in the Management of Refractory Rheumatoid Arthritis: Expert Insight on the Clinical Potential of Novel Therapeutic Options

Go online to PeerView.com/XQR860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in rheumatology discusses the role of novel therapeutic options in overcoming challenges associated with the management of patients with refractory rheumatoid arthritis. Upon completion of this activity, participants should be better able to: Recognize challenges associated with the management of refractory rheumatoid arthritis, Identify novel therapeutic options for rheumatoid arthritis in the context of mechanism of action, efficacy, and safety, Employ current evidence and expert recommendations into individualized treatment plans for patients with rheumatoid arthritis who have not achieved adequate disease control on previous therapies.
Source: PeerView CME/CE Audio Podcast - Immunology - Category: Allergy & Immunology Authors: Tags: Science, Medicine Source Type: podcasts

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We report this case to raise the importance of clinical alertness for the rare but possibly underdiagnosed disease.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Conclusion: There is a high prevalence of AID among patients with DLBCL. AIDs categorized as primarily B-cell mediated (in this study mainly RA, systemic lupus erythematosus and Sjögren's syndrome) may be associated with inferior OS. AID patients may be more prone to neutropenic fever compared to patients without concomitant AID. PMID: 31131659 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Publication date: Available online 11 May 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Giuseppe Benagiano, Marisa Benagiano, Paola Bianchi, Mario Milco D’Elios, Ivo BrosensAbstractAutoimmune diseases (AIDs) affect women with a 2 - 1 ratio vs. men, suggesting that hormonal contraceptives play a role in their clinical course.Combined oral contraceptives have complex, sometimes contradictory, effects on AIDs; they can worsen the situation in women with Systemic Lupus Erythematosus and with Antiphospholipid Syndrome, condition in which they are contraindicated. Early studies indi...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this study, we evaluated the effect of auranofin on the radiosensitivity of intestinal epithelial cells. The treatment with a combination of 1 μM auranofin and 5 Gy ionizing radiation showed clear additive effects on caspase 3 cleavage and apoptotic DNA fragmentation in IEC-6 cells, and auranofin administration significantly aggravated the radiation-induced intestinal injury in mice. Auranofin treatment also resulted in the activation of the unfolded protein response and in the inhibition of thioredoxin reductase, which is a key component of the cellular antioxidant system. Pre-treatment with N-acetyl cysteine, a wel...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc-dependent endopeptidases that play a critical role in the destruction of extracellular matrix proteins and, the shedding of membrane-bound receptor molecules in various forms of arthritis and other diseases. Under normal conditions, MMP, ADAM and ADAMTS gene expression aids in the maintenance of homeostasis. However, in inflamed synovial joints characteristic of rheumatoid arthritis and osteoarthritis. MMP, ADAM and ADAMTS production is greatly in...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
CONCLUSION: Our study shows the diagnostic value of auto antibodies in AIDs. It would be interesting to carry out prospective studies on each pathology separately, in order to fill the classic vagaries of the retrospective study and objectively estimate the prevalence in different AIDs. These data on the prevalence of each autoimmune disease are valuable for the public health system. PMID: 30807792 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research
A new randomized trial examined the effects of an intensive yoga regimen in people with rheumatoid arthritis and found that the practice aids remission.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news
FRIDAY, Dec. 14, 2018 -- A nurse-based phone education intervention can promote shared decision making in patients with newly diagnosed rheumatoid arthritis (RA), according to a study published online Dec. 5 in Musculoskeletal Care. Siobhan Farley,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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