18. Molecular Substrate of Impaired Working Memory in Schizophrenia: Differential Contributions of Cortical Regions and Cell Types

Visuospatial working memory (WM), which is impaired in schizophrenia, depends on a distributed network including primary visual (V1), association visual (V2), posterior parietal (PPC), and dorsolateral prefrontal (DLPFC) cortices. Information is conveyed across these regions via the excitatory projections of glutamatergic pyramidal neurons located in layer 3, whose activity is regulated by subsets of GABAergic neurons that express parvalbumin (PV), somatostatin (SST) or vasoactive intestinal polypeptide (VIP).

Source: Biological Psychiatry - May 13, 2019 Category: Psychiatry Authors: David Lewis, Gil Hoftman, Samuel Dienel, Makoto Tsubomoto, Takanori Hashimoto Source Type: research