O15. Intrinsic Brain Connectivity Moderators of Psychotherapy Response and Changes in PTSD: A Combined Connectomic, Network Level, and Seeded Connectivity Approach

Trauma-focused psychotherapy is a first-line treatment for post-traumatic stress disorder (PTSD). Treatment mechanisms are poorly understood, and heterogeneity in treatment response is vast. Brain phenotyping is a promising method to assess treatment suitability and identify treatment mechanisms, but an understanding of the neural processes underlying therapeutic benefit and facilitating favorable treatment response is nascent. Here, we assay intrinsic patterns of brain connectivity across multiple units of analysis (whole brain connectome, network-level interactions, and seeded connectivity of PTSD-relevant structures) to determine the intrinsic connectivity features most useful for identifying treatment mechanisms and outcome-predictive effects.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research

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Results of a new meta-analysis confirm recommendations for psychotherapy as a first-line therapy for posttraumatic stress disorder.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news
Are Drugs Always the Proper Solution to Therapeutic Dilemmas? Non-drug Approaches to the Post-traumatic Stress "Waking Corpse" Syndrome. Curr Pharm Des. 2019;25(1):1-4 Authors: Laios K, Tsoucalas G, Vrachatis DA, Charalampakis A, Androutsos G, Karamanou M Abstract Jules Cotard (1840-1889), a Parisian neurologist, described a syndrome of delirium negations which was later named after him. Some physicians in antiquity and medieval times, especially in Asia, have noticed this syndrome and categorized it as a symptom of melancholy. They have presented it as a "walking corpse syndrome",...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
This network meta-analysis compared 12 randomized clinical trials comprising 992 patients to assess the short- and long-term outcomes of psychotherapy, pharmacotherapy, and combination therapies for adults with posttraumatic stress disorder.
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research
We’ve come a long way since therapists prescribed to their clients to punch their pillows when angry as a cathartic way to release negative emotions. While it helped bring up the emotion, they left out a critical piece in recovery: connecting that emotion to the logical side of our brains. What the person felt was not relief but disassociation. What we know today in neuroscience and psychotherapy research is that when a traumatic event occurs, the brain goes into dysregulation. That is, the body and the mind become disconnected. Our survival or emotional part of our brain kicks in and calls the shots while our logic...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: PTSD Trauma Treatment Disassociation Emotional Dysregulation Resilience Trauma Informed care trauma recovery Validation Source Type: blogs
Conclusions and Relevance Identifying and treating P-PTSD have important implications for maternal and neonatal health. Few treatment studies exist for P-PTSD specifically, so combining P-PTSD research with current guidelines for PTSD is necessary to inform clinical practice. Target Audience Obstetricians and gynecologists, family physicians. Learning Objectives After participating in this CME activity, the participant should be better able to identify several risk factors for the development of PTSD in the perinatal period; describe 2 diagnostic tools to help diagnose and monitor P-PTSD; and compare effective and ...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME ARTICLES Source Type: research
AbstractPurpose of reviewPosttraumatic stress disorder (PTSD) and substance use disorders (SUD) are highly comorbid, and the presence of both disorders is associated with lower treatment effect sizes and higher dropout from treatment than one disorder alone. This review examines recent research on treatments for patients with comorbid PTSD/SUD, as well as recent work on psychological mechanisms that may contribute to both disorders.Recent findingsSeveral studies have shown that trauma-focused treatments, such as Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE), are effective for redu...
Source: Current Treatment Options in Psychiatry - Category: Psychiatry Source Type: research
Could a chatbot, an online community, or a telepsychiatry solution offer meaningful help for people who are fighting mental health issues? Could virtual reality, artificial intelligence, or genetics appear as elements of assistance in the toolkit of medical professionals in the fields dealing with the human psyche? While we agree that medical fields requiring the most empathy and human touch will most probably not be swept away by new innovations, we looked thoroughly at how technology will appear in the future of psychiatry. Perhaps even help heal the cursed prince from Beauty and the Beast? The human touch is indispen...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Virtual Reality in Medicine AI apps AR artificial intelligence digital health digital health technologies health apps Innovation mental health psychiatry psychology technology VR Source Type: blogs
We present first results of ketamine augmentation of intensive 7-day-PE (KPE) for PTSD patients.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
To see this abstract, please see Oral Abstract #O15.
Source: Biological Psychiatry - Category: Psychiatry Source Type: research
AbstractPurposeThe prevalence of posttraumatic stress disorder (PTSD) among patients in primary care clinics is higher than that of the general population and many people prefer to get mental health care in primary care, creating a unique opportunity to identify and treat the disorder. Current treatment guidelines recommend psychotherapy as a first-line treatment for PTSD; however, there is a limited amount of research examining effective psychotherapy treatment protocols for PTSD within primary care. This review aims to examine the existing literature for the treatment of PTSD in primary care and discuss ongoing dissemina...
Source: Current Treatment Options in Psychiatry - Category: Psychiatry Source Type: research
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