T130. Transcriptome Profile in iPSC-Derived Astrocytes of TCF7L2, a Transcription Factor Associated With Bipolar Disorder, Reveals Relationship With Neural Function

Bipolar Disorder (BD) has been associated with multiple phenotypic traits, including obesity. We previously performed genome-wide association studies (GWAS) for BMI-dependent BD risk and identified a genome-wide significant SNP mapped to the TCF7L2 gene. This signal was replicated in an independent cohort. TCF7L2 encodes a transcription factor in the Wnt/beta-catenin pathway. Genetic polymorphisms in TCF7L2 have been associated with type-2 diabetes risk. However, the role of TCF7L2 in neuropsychiatric disorders like BD is not well understood.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research