T208. Expression of Striatal Fibroblast Growth Factors in Rats After Escalated Oxycodone Self-Administration

Oxycodone is a semisynthetic opioid prescribed for moderate to severe pain. Recently, addiction to prescribed opioids has been tragic. Better treatment for opioid addiction is needed. To elucidate the neurobiological underpinnings of addiction to opioid drugs, we have used the model of oxycodone self-administration (SA) in rats. In the present study, we investigated the potential role of growth factors in oxycodone SA and withdrawal.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research

Related Links:

In this study, the stereotyped behaviors and cognitive functions related to different types of tactile and auditory inputs were investigated in the rats following chronic exposure to the morphine, methadone, and buprenorphine. Here, three addicted groups received morphine, methadone, and buprenorphine while the control rats received saline for 21 days. Our results demonstrated that the opioid-treated groups showed stereotyped behaviors including grooming and rearing. In the behavioral level, prepulse inhibition and preference indices were not changed significantly in the opioids-treated groups compared to those of the sali...
Source: Physiology and Behavior - Category: Physiology Source Type: research
AbstractThe primary objective of this article is to assist oncologists and advanced practice prescribers to safely and effectively minimize risk when providing opioids for cancer pain relief. The majority of people with cancer are unlikely to misuse or divert opioid medications, yet the prescriber is often unaware of those who are at risk for these behaviors. To provide skillful pain management to each patient in the oncology setting, while limiting harm to the community, all prescribers must consider the potential for risk of misuse, addiction, or diversion. To minimize this risk to the greatest degree possible, it is imp...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Symptom Management and Supportive Care Cancer Care and the Opioid Crisis Source Type: research
When someone has an addiction to Vicodin and is ready to become sober, there are many questions that may arise. These can include: Where should I go for treatment? How much will it cost? How long will treatment take? What is Vicodin withdrawal like? Since there are many unknowns when it comes to getting treatment for addiction, it is very important to do research and find out as much as you can. This way, you will feel more prepared when you enter treatment and will be able to become much more comfortable throughout the process. This includes knowing what to expect when you are detoxing from Vicodin and what it might feel...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Substance Abuse anxiety in withdrawal detox opioid opioids vicodin withdrawal symptoms Source Type: blogs
Oct 23, 2019. . Sponsored by Addiction Technology Transfer Center Network, National American Indian&Alaska Native
Source: Rural events via the Rural Assistance Center - Category: Rural Health Source Type: events
The last time I stuck a needle in my arm was three whole months before I conceived my son, and I’m grateful that he’s never experienced me in active addiction. I say three whole months as if it were a lifetime, but it really is to anyone in early recovery. I was fortunate, I stopped using heroin before I found out that I was pregnant. I had just turned 29 and was in a stable relationship with my now-husband. For many women, getting on methadone doesn’t happen until they find out they’re pregnant. Their options are to either keep using or get into treatment. I started taking methadone five months be...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction Pregnancy Publishers Recovery The Fix Heroin Methadone methadone withdrawal Opioids Pregnant Source Type: blogs
Date: Thursday, 12 19, 2019; Speaker: George F. Koob, Ph.D., Director, NIAAA; Building: Building 50; 1328/1334
Source: NIH Calendar of Events - Category: American Health Source Type: events
FRIDAY, Oct. 11, 2019 -- Taking opioids after a vasectomy doesn't improve pain control and is associated with increased risk of persistent use of the addictive painkillers months later, a new study says. It included 228 men who had vasectomies...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conclusions: Indian medical practitioners felt the need for formal pain management training. There is a lack of consensus on how to manage the pain using opioid analgesics. Tough regulations on medical and scientific use of opioids are the most commonly reported barrier to prescribing them.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
AbstractPurpose of ReviewKratom (Mitragyna speciosa) is an herb with no current indication for medical use with potentially addictive properties, yet it is being used in the management of pain, depression, and anxiety. The agent ’s pharmacology lends itself for concern regarding recreational misuse (Drugs of Abuse,2017).Recent FindingsKratom ’s increasing popularity for use in the USA is reflected by National Poison Data System data that in 2011 there were 13 cases reported to poison control centers while in 2017 there were 682 calls in response to kratom exposure (Kratom exposure in the US linked to serious me...
Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
According to Healthline, Oxycodone is used to treat moderate to severe pain. It can be used short term or long term, depending on your condition. It is an opioid oral tablet and is better known by its other generic brand names, including Oxaydo, Roxicodone, Roxybond, and OxyContin. It is available in five forms, and since it is an opioid medication, it can be very easy to form an Oxycodone addiction. If you feel as if you may be forming an addiction to Oxycodone, make sure you are aware of the signs, symptoms and when it’s time to get help. Oxycodone Addiction Warning Signs Oxycodone can be a very helpful tool for m...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Painkiller Substance Abuse opiate opiate addiction opioid opioids oxycodone oxycodone abuse prescription drug abuse prescription drug addiction prescription drug use prescription drugs pre Source Type: blogs
More News: Addiction | Brain | Neurology | Oxycodone | OxyContin | Pain | Psychiatry | Study