S149. Gene Expression in Dorsolateral Prefrontal Cortex: A Master Regulator Analysis of Major Psychiatric Disorders

Traditional genetic studies have failed to find individual genes of large effect size in major psychiatric disorders. Using network-based approaches, we aimed to (1) identify transcription factors acting as potential master regulators (MRs) in Bipolar Disorder (BD), Schizophrenia (SZ) and Major Depressive Disorder (MDD); (2) Investigate the activation/repression patterns of these MRs, as well as the enriched biological processes in each disorder, to characterize diseases ’ transcriptional phenotypes.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research