S149. Gene Expression in Dorsolateral Prefrontal Cortex: A Master Regulator Analysis of Major Psychiatric Disorders

Traditional genetic studies have failed to find individual genes of large effect size in major psychiatric disorders. Using network-based approaches, we aimed to (1) identify transcription factors acting as potential master regulators (MRs) in Bipolar Disorder (BD), Schizophrenia (SZ) and Major Depressive Disorder (MDD); (2) Investigate the activation/repression patterns of these MRs, as well as the enriched biological processes in each disorder, to characterize diseases ’ transcriptional phenotypes.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research

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ConclusionsOur results suggest a causal role of insomnia in autism spectrum disorder and bipolar disorder. Future disease models should include insomnia as a factor for these two disorders to develop effective interventions. More detailed mechanism studies may also be inspired by this causal inference.
Source: European Psychiatry - Category: Psychiatry Source Type: research
An in-depth look at violence and its relation to schizophrenia. Is violence a symptom of schizophrenia? Do mass attackers always have schizophrenia? Are schizophrenics dangerous? Studies say people with schizophrenia are more likely to be a victim of a crime than the perpetrator. However, James Holmes, the movie theater mass murderer, was said to have paranoid schizophrenia. And a person can plead not-guilty by reason of insanity in court. This seems to be contrary to the idea of non-violence in mental illness. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects i...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Stigma Violence and Aggression Mental Disorder Mental Health Mental Illness Paranoid Schizophrenia violence and mental illness violence and mentally ill Source Type: blogs
Kanye West’s interview about living with bipolar disorder has recently made the media rounds. Mr. West speaks about not liking medication, about mania being a creative outlet, and the career edge he believes he has because of living with mental illness. Suffice to say, whenever someone gains an audience by speaking about living with bipolar disorder, our hosts are going to take notice. Do they agree with Mr. West? Listen now to find out. SUBSCRIBE &REVIEW “Do you know many homeless schizophrenics who are eating well?” – Gabe Howard   Highlights From ‘Kanye West Bipolar’...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Minding the Media Source Type: blogs
Abstract Quetiapine is a common atypical antipsychotic used to treat mental disorders such as schizophrenia, bipolar disorder, and major depressive disorder. There has been increasing number of reports describing its cardiotoxicity. However, the molecular mechanisms underlying quetiapine-induced myocardial injury remain largely unknown. Herein, we reported a novel cell death type, quetiapine-induced necroptosis, which accounted for quetiapine cardiotoxicity in mice and proposed novel therapeutic strategies. Quetiapine-treated hearts showed inflammatory infiltration and evident fibrosis after 21-day continuous inje...
Source: Toxicology Letters - Category: Toxicology Authors: Tags: Toxicol Lett Source Type: research
Abstract Dopaminergic (DA) neurons are involved in many critical functions within the central nervous system (CNS), and dopamine neurotransmission impairment underlies a wide range of disorders from motor control deficiencies, such as Parkinson's disease (PD), to psychiatric disorders, such as alcoholism, drug addictions, bipolar disorders, schizophrenia and depression. Neural stem cell-based technology has potential to play an important role in developing efficacious biological and small molecule therapeutic products for disorders with dopamine dysregulation. Various methods of differentiating DA neuron...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
CONCLUSIONS: Modifiable predictors of supported employment outcomes included cognitive functioning and negative symptom severity; thus, interventions to improve these factors may improve work outcomes and decrease the loss of productivity associated with severe mental illness. PMID: 31185856 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
CONCLUSIONS: Half of those who died by suicide had at least one diagnosed mental health condition in the year before death, and most mental health conditions were associated with an increased risk of suicide. Findings suggest the importance of suicide screening and providing an approach to improve awareness of mental health conditions. PMID: 31185853 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
Publication date: Available online 12 June 2019Source: The LancetAuthor(s): Fiona Charlson, Mark van Ommeren, Abraham Flaxman, Joseph Cornett, Harvey Whiteford, Shekhar SaxenaSummaryBackgroundExisting WHO estimates of the prevalence of mental disorders in emergency settings are more than a decade old and do not reflect modern methods to gather existing data and derive estimates. We sought to update WHO estimates for the prevalence of mental disorders in conflict-affected settings and calculate the burden per 1000 population.MethodsIn this systematic review and meta-analysis, we updated a previous systematic review by searc...
Source: The Lancet - Category: General Medicine Source Type: research
Common problems include depression, anxiety, post-traumatic stress disorder, bipolar disorder or schizophrenia, according to the World Health Organization. About 9% have a moderate to severe mental health condition.
Source: WebMD Health - Category: Consumer Health News Source Type: news
AbstractBackgroundMultiple sclerosis (MS) is characterized by a large spectrum of symptoms, involving all functional systems. Psychiatric symptoms are common in people with MS (pwMS) having an important impact on quality of life and on some features of MS (fatigue, sleep, disability, adherence to disease-modifying drugs). The main psychiatric disturbances in MS are depressive, bipolar, anxiety, schizophrenic and obsessive –compulsive syndromes.MethodsLiterature search for original articles and review in the databases, including PubMed and Scopus from 1959 to 2019.Results and conclusionStudies answering the aim of thi...
Source: Journal of Neurology - Category: Neurology Source Type: research
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