Preventing cell death as novel therapeutic strategy for rheumatoid arthritis

(VIB (the Flanders Institute for Biotechnology)) A collaborative study by research groups from the University of Cologne, VIB, Ghent University, theΒiomedical Sciences Research Center 'Alexander Fleming' in Athens and the University of Tokyo identified a new molecular mechanism causing rheumatoid arthritis. The researchers found that death of macrophages, an immune cell type, can trigger the disease. Moreover, they discovered how the protein A20 prevents macrophage death and protects against arthritis. These findings open up new possibilities for the treatment of this debilitating disease.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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In this study, we identified AIRE as a cytokine-induced RA risk gene in RA FLS and explored its role in these pathogenic stroma cells. Using RNA interference and RNA sequencing we show that AIRE does not induce TRAs in FLS, but augments the pro-inflammatory response induced by tumor necrosis factor and interleukin-1beta by promoting the transcription of a set of genes associated with systemic autoimmune disease and annotated as interferon-gamma regulated genes. In particular, AIRE promoted the production and secretion of a set of chemokines, amongst them CXCL10, which have been associated with disease activity in RA. Final...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
MONDAY, June 17, 2019 -- For patients with rheumatoid arthritis (RA) achieving low disease activity or remission with tocilizumab (TCZ), glucocorticoid (GC) tapering (GCtaper) is associated with a small but significant increase in disease activity...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Nature Reviews Rheumatology, Published online: 17 June 2019; doi:10.1038/s41584-019-0253-3Changes in the gut microbiome are thought to be important environmental triggers for inflammatory forms of arthritis, including rheumatoid arthritis. Could interactions between gut parasites, such as helminths, and gut microbiota be the key to normalizing an unbalanced microbiome and preventing arthritis?
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
This study was undertaken to assess the correlation of positron emission tomography (PET) –derived parameters in 68 joints with disease activity and to compare the reliability of joint counts between PET with computed tomography (CT) and clinical assessment in patients with rheumatoid arthritis (RA).MethodsWe enrolled 91 patients with active RA (69 in a development group and 22 in a validation group) who underwent concurrent18F ‐fluorodeoxyglucose (18F ‐FDG)–PET‐CT and clinical disease activity evaluation. PET‐derived parameters were compared with disease activity assessed using clinical joint count par...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
J Knee Surg DOI: 10.1055/s-0039-1692397There are conflicting results regarding the impact of rheumatoid arthritis (RA) on total knee arthroplasty (TKA) outcomes. Therefore, the purpose of this study was to compare outcomes of patients with and without RA undergoing primary TKA. Specifically, we assessed (1) 90-day medical complications, (2) 90-day readmission rates, (3) short-term implant-related complications, (4) 1-year mortality, and (5) total global 90-day episode-of-care costs. The authors of the study hypothesize that RA would increase the rate of medical- and implant-related complications, readmission rates, and cos...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Special Focus Section Source Type: research
Publication date: August 2019Source: Molecular Immunology, Volume 112Author(s): Elizabeth A. Bemis, Jill M. Norris, Jennifer Seifert, Ashley Frazer-Abel, Yuko Okamoto, Marie L. Feser, M. Kristen Demoruelle, Kevin D. Deane, Nirmal K. Banda, V. Michael HolersAbstractRheumatoid arthritis (RA) is a complex autoimmune disease with an etiology that is not yet well understood, disproportionally affects women and also varies in incidence and prevalence by population. The presence of anti-citrullinated protein antibodies (ACPA) is a highly specific biomarker for the diagnosis of clinically apparent RA. ACPA are also present in the ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: The IR of CV events in our Italian multicentre cohort was lower than that reported in other European and non-European cohorts. Low-dose ASA may have a role in the primary prophylaxis of CV events in RA patients. PMID: 31192004 [PubMed]
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
ConclusionsCXCL8 and CXCL10 are potential predictors of JIA and RA. CXCL10 is a more significant predictor. The CXCL16 was not found to have such impact and it might be of value in a subgroup of seropositive RA patients.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
CONCLUSION: Although the overall OS rate has not changed, there is a decrease in the rate of arthrodesis at all ages, THA in patients under 80 years of age, as well as TKA and ULA in patients under 60 years of age. PMID: 31203231 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
CONCLUSION: Compared with csDMARDs and/or steroids without ABT, adding ABT to the treatment does not appear to increase the incidence rates of postoperative adverse events in RA patients undergoing orthopedic surgery. Large cohort studies should be performed to add evidence for the perioperative safety profile of ABT. PMID: 31203226 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
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