Acacetin—A simple flavone exhibiting diverse pharmacological activities

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Ruchi Badoni Semwal, Deepak Kumar Semwal, Sandra Combrinck, Jeanne Trill, Simon Gibbons, Alvaro ViljoenAbstractAcacetin (5,7-dihydroxy-4-methoxyflavone) is a naturally occurring flavonoid, known to possess numerous pharmacological properties, including neuroprotective, cardioprotective, anticancer, anti-inflammatory, antidiabetic, and antimicrobial activities. The molecule is widespread throughout the Plant Kingdom, but is particularly abundant in the Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae and Malvaceae families. It has been shown to exhibit strong inhibitory effects against glutathione reductase, cyclo-oxygenase, acetylcholinesterase, aldose reductase and xanthine oxidase enzymes. A comprehensive overview of the potential therapeutic applications of acacetin was prepared after collating selected peer-reviewed papers, accessed from online scientific databases, specifically PubMed, Web of Science and Scopus. The mechanism of action, dose forms and structure-activity relationships of the molecule are some of the aspects discussed in the review, to facilitate further research and use of this molecule.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research