Predicting Unbound Phenytoin Concentrations: Effects of Albumin Concentration and Kidney Dysfunction

ConclusionIn patients with normal albumin concentrations, with or without mild or moderate kidney dysfunction and not receiving a protein ‐binding displacer, the free fraction of phenytoin is unchanged, and it is not necessary to measure a free phenytoin concentration. Free phenytoin concentrations should be measured directly in patients with hypoalbuminemia and kidney dysfunction.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research