Serotonin1B Receptor-Mediated Presynaptic Inhibition of Proprioceptive Sensory Inputs to Jaw-Closing Motoneurons.
Serotonin1B Receptor-Mediated Presynaptic Inhibition of Proprioceptive Sensory Inputs to Jaw-Closing Motoneurons. Brain Res Bull. 2019 May 07;: Authors: Nagata A, Nakayama K, Nakamura S, Mochizuki A, Gemba C, Aoki R, Dantsuji M, Maki K, Inoue T Abstract The proprioceptive sensory inputs from neurons in the mesencephalic trigeminal nucleus (MesV) to masseter motoneurons (MMNs) play an important role in regulating masseter muscle activity during mastication. Several histological studies have shown that serotonin (5-HT) fibers densely innervate both the MesV and the trigeminal motor nucleus. However, the functional roles of 5-HT in the regulation of the excitatory synaptic inputs from MesV afferents to MMNs remain to be clarified. Thus, using the whole-cell recording technique in brainstem slice preparations from juvenile Wistar rats aged between postnatal days 8 and 12, we examined the effects of 5-HT on the excitatory synaptic inputs from MesV afferents to MMNs. Bath application of 5-HT reduced the peak amplitude of excitatory postsynaptic potentials evoked in MMNs by electrical stimulation of the MesV afferents (eEPSPs), and this inhibitory effect of 5-HT on eEPSPs was replicated with the 5-HT1B receptor agonist CP-93129 but not by the 5-HT1A receptor agonist 8-OH-DPAT. Moreover, the 5-HT1B receptor antagonist SB-224289 but not the 5-HT1A receptor antagonist WAY-100635 antagonized the inhibitory effect of 5-HT on eEPSPs. CP-93129 increased the paired-pul...
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Readers who found these articles interesting may also like to read these papers that can be found in recent issues of our sister publications, Seminars in Thoracic and Cardiovascular Surgery and Operative Techniques in Thoracic and Cardiovascular Surgery.
Re: Yang CJ, Kumar A, Gulack BC, Mulvihill MS, Hartwig MG, Wang X, et al. Long-term outcomes after lobectomy for non–small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis. J Thoracic Cardiovasc Surg. 2016;151:1380-8.
Dr M. Jacobs (Baltimore, Md). The Norwood procedure, the most commonly performed open operation in the neonatal age group, was developed approximately 40 years ago by Dr William Norwood. This operation has probably been the subject of as many or more investigations or reports than any other operation for congenital heart disease, yet Dr Mascio and colleagues stated accurately in their article that the principles of the Norwood operation remain esse ntially the same today as when Norwood first conceived it.