Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins.

Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins. Exp Neurol. 2019 May 08;: Authors: Sanchez-Bezanilla S, TeBay C, Nilsson M, Walker FR, Ong LK Abstract Numerous clinical studies have documented the high incidence of cognitive impairment after stroke. However, there is only limited knowledge about the underlying mechanisms. Interestingly, there is emerging evidence suggesting that cognitive function after stroke may be affected due to reduced waste clearance and subsequent accumulation of neurotoxic proteins. To further explore this potential association, we utilised a model of experimental stroke in mice. Specifically, a photothrombotic vascular occlusion targeting motor and sensory parts of the cerebral cortex was induced in young adult mice, and changes in cognition were assessed using a touchscreen platform for pairwise visual discrimination. The results showed that the execution of the visual discrimination task was impaired in mice 10 to 14 days post-stroke compared to sham. Stroke also induced significant neuronal loss within the peri-infarct, thalamus and the CA1 sub-region of the hippocampus. Further, immunohistochemical and protein analyses of the selected brain regions revealed an increased accumulation and aggregation of both amyloid-β and α-synuclein. These alterations were associated with...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

Related Links:

Getting the right care in a timely manner is important in medical emergencies. In the event that you or a loved one suffers a stroke, time is especially critical. “In the event of a stroke, a delay of only 15 minutes in treatment greatly decreases your chances not only of making a full recovery, but also being able to walk or live independently, and in many cases, of survival,” says Christopher Zammit, MD, a critical care specialist and emergency physic ian with TriHealth, which offers a network…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Authors: Zhang Y, Liu Y, Zhu J, Zhai S, Jin R, Wen C Abstract The Traditional Chinese Medicine (TCM) formula is the main treatment method of TCM. A formula often contains multiple herbs where core herbs play a critical therapeutic effect for treating diseases. It is of great significance to find out the core herbs in formulae for providing evidences and references for the clinical application of Chinese herbs and formulae. In this paper, we propose a core herb discovery model CHDSC based on semantic analysis and community detection to discover the core herbs for treating a certain disease from large-scale literatur...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
Today, approximately 20% of the U.S. population — about 60 million people — live in rural areas, which make up 97% of the land area in the United States. People living in rural America have less access to health care and are more likely than residents of urban areas to die from chronic conditions such as heart disease, cancer, stroke, and chronic lower respiratory disease. Moreover, long-standing systemic health and social inequities have put many rural residents at increased risk of getting COVID-19. The rural/urban inequities in health and health care warrant more rigorous and innovative scientific research t...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Condition:   Stroke Interventions:   Device: Virtual Reality;   Device: Action Observation Therapy;   Device: Landscape video;   Other: Standard treatment Sponsor:   Fondazione Don Carlo Gnocchi Onlus Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   SARS-CoV-2;   Post-stroke Depression;   Anxiety and Fear Intervention:   Sponsor:   Fatih Sultan Mehmet Training and Research Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stroke Intervention:   Behavioral: Narrative and Skills-building Intervention Sponsor:   Chinese University of Hong Kong Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke;   Brain Injuries, Traumatic;   Brain Tumor Benign Intervention:   Device: Indego Therapy Sponsor:   IRCCS San Raffaele Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 22 September 2020Source: NeuroscienceAuthor(s): Qian Jiang, Xiaokun Geng, Johnathan Warren, Eric Eugene Paul Cosky, Shawn Kaura, Christopher Stone, Fengwu Li, Yuchuan Ding
Source: Neuroscience - Category: Neuroscience Source Type: research
We report a case of ischemic stroke in the area of a DVA after minor...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
The decision by the U.S. Centers for Medicare and Medicaid Services' earlier...Read more on AuntMinnie.comRelated Reading: C-MIMI: Use of AI in radiology is evolving Medical imaging AI market projected for strong growth CMS approves payments for Viz.ai software AI, radiomics can predict stroke treatment success Viz.ai debuts new stroke care AI platform
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
More News: Brain | Neurology | Stroke | Study