Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins.

Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins. Exp Neurol. 2019 May 08;: Authors: Sanchez-Bezanilla S, TeBay C, Nilsson M, Walker FR, Ong LK Abstract Numerous clinical studies have documented the high incidence of cognitive impairment after stroke. However, there is only limited knowledge about the underlying mechanisms. Interestingly, there is emerging evidence suggesting that cognitive function after stroke may be affected due to reduced waste clearance and subsequent accumulation of neurotoxic proteins. To further explore this potential association, we utilised a model of experimental stroke in mice. Specifically, a photothrombotic vascular occlusion targeting motor and sensory parts of the cerebral cortex was induced in young adult mice, and changes in cognition were assessed using a touchscreen platform for pairwise visual discrimination. The results showed that the execution of the visual discrimination task was impaired in mice 10 to 14 days post-stroke compared to sham. Stroke also induced significant neuronal loss within the peri-infarct, thalamus and the CA1 sub-region of the hippocampus. Further, immunohistochemical and protein analyses of the selected brain regions revealed an increased accumulation and aggregation of both amyloid-β and α-synuclein. These alterations were associated with...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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Getting the right care in a timely manner is important in medical emergencies. In the event that you or a loved one suffers a stroke, time is especially critical. “In the event of a stroke, a delay of only 15 minutes in treatment greatly decreases your chances not only of making a full recovery, but also being able to walk or live independently, and in many cases, of survival,” says Christopher Zammit, MD, a critical care specialist and emergency physic ian with TriHealth, which offers a network…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
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Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
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Condition:   Stroke Interventions:   Device: Virtual Reality;   Device: Action Observation Therapy;   Device: Landscape video;   Other: Standard treatment Sponsor:   Fondazione Don Carlo Gnocchi Onlus Recruiting
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Conditions:   SARS-CoV-2;   Post-stroke Depression;   Anxiety and Fear Intervention:   Sponsor:   Fatih Sultan Mehmet Training and Research Hospital Completed
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Condition:   Stroke Intervention:   Behavioral: Narrative and Skills-building Intervention Sponsor:   Chinese University of Hong Kong Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Stroke;   Brain Injuries, Traumatic;   Brain Tumor Benign Intervention:   Device: Indego Therapy Sponsor:   IRCCS San Raffaele Recruiting
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Publication date: Available online 22 September 2020Source: NeuroscienceAuthor(s): Qian Jiang, Xiaokun Geng, Johnathan Warren, Eric Eugene Paul Cosky, Shawn Kaura, Christopher Stone, Fengwu Li, Yuchuan Ding
Source: Neuroscience - Category: Neuroscience Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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