Oxygenation strategies for encapsulated islet and beta cell transplants.
Oxygenation strategies for encapsulated islet and beta cell transplants.
Adv Drug Deliv Rev. 2019 May 08;:
Authors: Papas KK, De Leon H, Suszynski TM, Johnson RC
Abstract
Human allogeneic islet transplantation (ITx) is emerging as a promising treatment option for qualified patients with T1D. However, widespread clinical application of allogeneic ITx is hindered by two critical barriers: the need for systemic immunosuppression and the limited supply of human islet tissue. Biocompatible, retrievable immunoisolation devices containing glucose-responsive insulin-secreting tissue may address both critical barriers by enabling the more effective and efficient use of allogeneic islets without immunosuppression in the near-term, and ultimately the use of a cell source with a virtually unlimited supply, such as human stem cell derived β-cells or xenogeneic (porcine) islets with minimal or no immunosuppression. However, even though encapsulation have been developed and immunoprotection has been successfully tested in small and large animal models and to a limited extent in proof of concept clinical studies, the effective use of encapsulation approaches to convincingly and consistently treat diabetes in humans has yet to be demonstrated. There is increasing consensus that inadequate oxygen supply is a major factor limiting their clinical translation and routine implementation. Poor oxygenation negatively affects cell viability and β-cell func...
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Papas KK, De Leon H, Suszynski TM, Johnson RC Tags: Adv Drug Deliv Rev Source Type: research
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