New vaccine introductions in Africa before and during the decade of vaccines - Are we making progress?

New vaccine introductions in Africa before and during the decade of vaccines - Are we making progress? Vaccine. 2019 May 07;: Authors: Sambala EZ, Wiyeh AB, Ngcobo N, Machingaidze S, Wiysonge CS Abstract Vaccines are excellent investments with far-reaching rewards beyond individual and population health, but their introduction into national programs has been historically slow in Africa. We provide an overview of the introduction of new and underutilized vaccines in countries of the WHO African Region by 2017, using data from the WHO-UNICEF Joint Reporting Form. By 2017, all 47 countries had introduced vaccines containing hepatitis B (compared to 11% in 2000 and 98% in 2010) and Haemophilus influenzae type b (Hib) (compared to 4% in 2000 and 91% in 2010). The proportion of countries that had introduced other vaccines by 2017 was 83% for pneumococcal conjugate vaccine (PCV) from 7% in 2010, 72% for rotavirus vaccine from 2% in 2010, 55% for the second dose of a measles-containing vaccine (MCV2) (compared to 11% in 2000 and 17% in 2010), and 45% for rubella-containing vaccines (RCV) (compared to 4% in 2000 and 7% in 2010). From 2000 to 2010, there was no significant difference between countries eligible (N = 36) and those not eligible (N = 10) for Gavi support in the introduction of hepatitis B and PCV. However, Gavi eligible countries were more likely to introduce Hib and non-Gavi eligible countries were more likely to introduce MCV2 and RCV. From ...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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Data from a federal program designed to compensate people harmed by vaccines shows how rare it is for someone to claim they were hurt after getting vaccinated.
Source: NYT - Category: American Health Authors: Tags: Vaccination and Immunization Tetanus Measles Drugs (Pharmaceuticals) Autism Medicine and Health Centers for Disease Control and Prevention National Vaccine Injury Compensation Program Health and Human Services Department your-feed-health Source Type: news
In this study, we performed 2D-DIGE and MALDI-TOF/TOF MS to analyze differentially expressed proteins between HeLa and invasive HeLa-I5 cells..Key findingsAccording to our proteomics data, 68 differentially expressed proteins between the HeLa and HeLa-I5 cells were identified. One of these differentially expressed proteins, Progesterone receptor membrane component 1 (PGRMC1), was selected as a candidate for further studies. To correlate the role of PGRMC1 with cellular migration and cancer progression, small interfering RNA (siRNA) was used to knockdown the expression of PGRMC1. Similar function of PGRMC1 was also observed...
Source: Life Sciences - Category: Biology Source Type: research
Parkinson disease may join the list of extrahepatic complications associated with HCV infection, according to a new study in JAMA Neurology.
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Hepatitis C Infectious Disease Source Type: news
In this study, groups of chickens were vaccinated twice intramuscularly at 14-day interval either with plasmid DNA encoding F protein gene of NDV or with recombinant F protein alone or with plasmid DNA and boosted with the recombinant F protein and compared with birds that were vaccinated with live NDV vaccine. The immune response was evaluated by indirect ELISA, lymphocyte transformation test, virus neutralization test, cytokine analysis, immunophenotyping of peripheral blood mononuclear cells, and protective efficacy study against virulent NDV challenge virus infection. Chickens in prime-boost group developed a higher le...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
Cytokines and chemokines are key signaling molecules of the immune system. Recent technological advances enable measurement of multiplexed cytokine profiles in biological samples. These profiles can then be used to identify potential biomarkers of a variety of clinical phenotypes. However, testing for such associations for each cytokine separately ignores the high context-dependent covariation in cytokine secretion and decreases statistical power to detect associations due to multiple hypothesis testing. Here we present CytoMod - a novel data-driven approach for analysis of cytokine profiles that uses unsupervised clusteri...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Pigs are important livestock and comprehensive understanding of their immune responses in infections is critical to improve vaccines and therapies. Moreover, similarities between human and swine physiology suggest that pigs are a superior animal model for immunological studies. However, paucity of experimental tools for a systematic analysis of the immune responses in pigs represent a major disadvantage. To evaluate the pig as a biomedical model and additionally expand the knowledge of rare immune cell populations in swine, we established a multicolor flow cytometry analysis platform of surface marker expression and cellul...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Isoniazid resistance in TB may be prevented and even reversed by a small newly identified molecule called C10, according to a recent study.
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Hepatitis C Infectious Disease Source Type: news
Children with asthma and recurrent wheezing can safely receive the nasal spray influenza vaccine, a large study found.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
Dr. Zhijian (James) Chen of the UT Southwestern Medical Center in Dallas will be the 2019 recipient of the Switzer Prize, awarded by the  David Geffen School of Medicine at UCLA. Chen has performed groundbreaking work on the mechanisms underlying the cellular response to infection.Chen ’s group has been instrumental in the identification of immune response pathways that have significantly added to scientists’ understanding of how these pathways work in microbial infections and autoimmune diseases.Most significantly, his team at UT Southwestern discovered the DNA-sensing enzyme cGAS, which helps launch the ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Discussion Vaccines are a mainstay of infectious disease prevention and health promotion. Infants, children and adults benefit from vaccines the most when they are given on the recommended schedules. However there are times when this is not possible as children come to the physician a little early, or a little late, or had unavailable records and so received addition vaccine, etc. There are many questions that arise because of these timing issues such as the one above. Standard vaccine schedules can be reviewed here. Commonly administered vaccines includes: Live-attenuated vaccines Cholera Measles, mumps, rubella (MMR ...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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