A systematic review of non-pharmacological interventions to improve therapeutic adherence in tuberculosis

ConclusionsGreat variability exists in the studies comparing strategies for identifying interventions, objectives and effects. The designs carried out generally have methodological deficits.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research

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In the beginning, there were single-cell bacteria. They were the only life on earth for billions of years, then larger cells evolved, then multicellular organisms, and then plants and animals. But the bacteria never went away, and all organisms, including us humans, have had to learn to live with them. Today, the lessons they are teaching us could change the trajectory of human health for generations. When bacteria were first discovered more than three centuries ago, most attention was on the ones we fought, which caused diseases like cholera, typhoid and tuberculosis. Through vaccines and antibiotics, we have made amazing...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news
Shervi Lie1†, Elise Rochet1†, Erik Segerdell2, Yuefang Ma1, Liam M. Ashander1, Audra M. A. Shadforth3,4, Timothy A. Blenkinsop5, Michael Z. Michael6, Binoy Appukuttan1,6, Beth Wilmot2 and Justine R. Smith1,6* 1Eye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia 2Department of Biostatistics, Oregon Health and Sciences University, Portland, OR, United States 3Queensland Eye Institute, Brisbane, QLD, Australia 4School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia 5Departments of Cell, Developmental and Regener...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Human trafficking is estimated to be the second largest criminal activity in the world after illegal arms trafficking. It affects all nations with an estimated 27 million people of all ages worldwide but only a small number are identified. It is defined by the United Nations as “the recruitment, transfer, harboring, or receipt of persons by means of threat or use of force or other forms of coercions, abduction, fraud, deception, the abuse of power, or a position of vulnerability to achieve the consent of a person, having control over another person, for the purpose of exploitation.” It includes comme...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Abstract More than 750,000 persons in the United States inject opioids, methamphetamine, cocaine, or ketamine, and that number is increasing because of the current opioid epidemic. Persons who inject drugs (PWID) are at higher risk of infectious and noninfectious skin, pulmonary, cardiac, neurologic, and other causes of morbidity and mortality. Nonjudgmental inquiries about current drug use can uncover information about readiness for addiction treatment and identify modifiable risk factors for complications of injection drug use. All PWID should be screened for human immunodeficiency virus infection, latent tuberc...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Abstract Heroin is a highly abused opioid that has reached epidemic status within the United States. Yet, existing therapies to treat addiction are inadequate and frequently result into rates of high recidivism. Vaccination against heroin offers a promising alternative therapeutic option but requires further development to enhance the vaccine's performance. Hsp70 is a conserved protein with known immunomodulatory properties and is considered an excellent immunodominant antigen. Within an antidrug vaccine context, we envisioned Hsp70 as a potential dual carrier-adjuvant, wherein immunogenicity would be increased by...
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Tags: Bioorg Med Chem Source Type: research
Tuberculosis (TB) is one of most important non-obstetric causes of maternal death. The aim of study was to estimate TB morbidity in pregnant and postpartum women (PW) in Gomel region as well as risk factors and level of drug resistance. Proportions are presented with 95% CI computed by the modified Wald method. We studied all new cases of lung TB found in PW in 2013-2016 - 51 patients, the proportion was 11.2% (8.5-14.5) of all women aged 18-45. TB incidence was 50.9 per 100000 deliveries which is reliably higher than in control group (women aged 18-45 excepting PW, TB incidence was 31,6 per 100000 women), p=0.03. 19.6% (1...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Background: Pulmonary tuberculosis (TB) is endemic in jail. But epidemiological data about risk factors for TB remains very little known in Tunisian patients with history of incarceration.Purpose: To determine the frequency of risk factors for TB in patients with history of incarceration and treated for TB.Methods: A retrospective case control study conducted between 2010 and 2016, including 232 male patients treated for TB in respiratory department C (Abderrahmen Mami Hospital). Patients were divided into 2 groups: G1 was including 58 patients who were incarcerated and G2 was including 174 patients without any history of ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
This article summarizes a presentation by R. Douglas Bruce, MD, MA, MS, at the IAS-USA continuing education program held in Chicago, Illinois, in May 2018. PMID: 30384332 [PubMed - in process]
Source: Topics in antiviral medicine - Category: Infectious Diseases Tags: Top Antivir Med Source Type: research
This study aimed to assess such risk factors in Hong Kong, which has an intermediate TB burden and low HIV prevalence. METHODS: We conducted a retrospective cohort analysis of adult patients reported to the Hong Kong TB-HIV Registry between 2006 and 2015. Baseline characteristics were compared with Kaplan-Meier estimates. Cox proportional hazards regression modelling was used to identify factors associated with mortality. RESULTS: Of 299 patients studied, 21 (7.0%) died within 12 months of anti-TB treatment (median [interquartile range], 7.5 [3.8-10] months). The median age of death was 54 (interquartile range, 40....
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
Amedeo Modigliani and his "great secret": a brief history of medical and social aspects of tuberculosis in the nineteenth and early twentieth century. Infez Med. 2018 Sep 01;26(3):280-282 Authors: Perciaccante A, Coralli A, Appenzeller O Abstract The pathography of the famous painter and sculptor Amedeo Modigliani (1884-1920) shows that he had tuberculosis and died of tubercular meningitis aged 35. The nineteenth century was characterized by numerous milestones in the history of tuberculosis. In 1853, Hermann Brehmer, first used the term tuberculosis referred to at the time as "phthisis&...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
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