Effect of irradiation time on biological effectiveness and tumor control probability in proton therapy

An effect of the irradiation time on the biological effectiveness was systematically evaluated in proton therapy for various target sizes, depths and prescribed doses per fraction. Spread-out Bragg peak plans were created using a constant relative biological effectiveness of 1.1 and the biological doses were then calculated based on the microdosimetric kinetic model. The biological dose large decreased with longer irradiation time or higher prescribed dose.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research

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Source: Health News from Medical News Today - Category: Consumer Health News Tags: Breast Cancer Source Type: news
Abstract Positron emission tomography (PET) has been extensively studied and clinically investigated for dose verification in proton therapy. However, the production distributions of positron emitters are not proportional to the dose distribution. Thus, direct dose evaluation is limited when using the conventional PET-based approach. We propose a method for estimating the dose distribution from the positron emitter distributions using the maximum likelihood (ML) expectation maximization (EM) algorithm combined with filtering. In experiments to verify the effectiveness of the proposed method, mono-energetic and spr...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
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Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Conclusions: Actigraphy was highly sensitive and accurate and was a reliable measure of SE and SL. Although there were differences in TST and WASO measurements by actigraphy and PSG, our findings provide the basis for future studies on the use of actigraphy to monitor treatment response to wakefulness-promoting medications in youth with craniopharyngioma who demonstrate excessive daytime sleepiness. PMID: 31303059 [PubMed - as supplied by publisher]
Source: Behavioral Sleep Medicine - Category: Sleep Medicine Authors: Tags: Behav Sleep Med Source Type: research
The University of Kansas Health System signed an agreement with global medical technology company IBA to buy a proton therapy system, which is a highly specialized form of radiation treatment that will be offered through the University of Kansas Cancer Center. The $39 million-$45 million contract includes the price for a ProteusONE unit and a long-term operation and maintenance agreement. KU Health anticipates breaking ground on a new proton therapy center to house the treatment system later this…
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STOCKHOLM, July 11, 2019 -- (Healthcare Sales &Marketing Network) -- The James M. Slater, MD Proton Treatment and Research Center at Loma Linda University Medical Center, US, has chosen the treatment planning system (TPS) RayStation®* to replace its ... Devices, Radiology, Oncology RaySearch Laboratories, RayStation, treatment planning system, proton therapy
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Palo Alto, Calif., July 9, 2019 /PRNewswire/ -- Varian (NYSE: VAR) celebrated the installation of the cyclotron for its ProBeam® Compact single-room proton therapy system at the King Chulalongkorn Memorial Hospital in Bangkok, Thailand on June 20, 2019. HRH Princess Maha Chakri Sirindhorn presided over the rigging ceremony. The cyclotron is a core piece of equipment of the ProBeam proton therapy system. This installation marks a key milestone for the first proton therapy...This story is related to the following:Radiotherapy Systems |
Source: Industrial Newsroom - Health, Medical and Dental Supplies - Category: Medical Devices Source Type: news
Proton beam therapy is a rapidly developing tool in cancer treatment. This educational piece will outline the key physical, biological and clinical parameters that give a basic understanding of the radiobiology of proton therapy (Figure  1). In particular, it will focus on the important parameters of linear energy transfer (LET) and relative biological effectiveness (RBE).
Source: Clinical Oncology - Category: Radiology Authors: Tags: Editorial Source Type: research
Our institution utilizes both biologic and standard dose models in spot scanning proton treatment planning. This analysis examines the rates of post-treatment radiologic change as detected on post-treatment MRI scans, and toxicities for pediatric brain tumor patients treated during the first year of our institution ’s experience. Our novel biologic dose model was found to demonstrate greater volumetric overlap with the post-treatment radiologic changes, than the standard dose model.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
CONCLUSION: We have carried out an extensive measurement of H*(10) under different conditions. The shielding thickness of our PT facility is adequate to limit the dose to occupational worker and general public within the permissible stipulated limit. The data reported here can bridge the knowledge gap in ambient dose around PT facility and can also be used as a reference for any new and existing proton facility for inter comparison and validation. ADVANCES IN KNOWLEDGE: First extensive investigation of neutron and photon H*(10) around PT facility and can bridge the knowledge gap on ambient dose. PMID: 31287739 [P...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
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