Effect of irradiation time on biological effectiveness and tumor control probability in proton therapy

An effect of the irradiation time on the biological effectiveness was systematically evaluated in proton therapy for various target sizes, depths and prescribed doses per fraction. Spread-out Bragg peak plans were created using a constant relative biological effectiveness of 1.1 and the biological doses were then calculated based on the microdosimetric kinetic model. The biological dose large decreased with longer irradiation time or higher prescribed dose.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research