Putative Nox2 Inhibitors Worsen Homocysteine-Induced Impaired Acetylcholine-Mediated Relaxation

Increased homocysteine (Hcy) is associated with coronary artery disease (CAD). Hcy increases reactive oxygen species (ROS) via NADPH oxidases (Nox), reducing acetylcholine-mediated vasorelaxation. We aimed to determine if putative Nox2 inhibitors prevent Hcy-impaired acetylcholine-mediated vasorelaxation.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - May 10, 2019 Category: Nutrition Authors: Renee M. Smith, Sudarshan Rai, Peter Kruzliak, Alan Hayes, Anthony Zulli Source Type: research