Dyskinesia-Hyperpyrexia Syndrome in Parkinson's disease with Deep Brain Stimulation and high-dose levodopa/carbidopa and entacapone

Dyskinesia-Hyperpyrexia Syndrome (DHS) is a rare hyperkinetic emergency, defined by the presence of severe, continuous, generalized, acute onset dyskinesias associated with increased creatine kinase (CK), hyperpyrexia and altered mental state, which affects patients with advanced Parkinson's disease (PD). It typically occurs in patients with long disease duration, undergoing high dopaminergic daily dose, and can be triggered by therapeutic changes, infections, hot weather, dehydration, or trauma.

Source: Parkinsonism and Related Disorders - May 10, 2019 Category: Neurology Authors: Alessio Novelli, Ilaria Antonella Di Vico, Federica Terenzi, Sandro Sorbi, Silvia Ramat Tags: Correspondence Source Type: research