The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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Publication date: Available online 3 June 2020Source: Life SciencesAuthor(s): Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Vahideh Zarrin, Ebrahim Rahmani Moghadam, Amirhossein Zabolian, Shima Tavakol, Saeed Samarghandian, Masoud Najafi
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 24 September 2020Source: Inorganica Chimica Acta, Volume 510Author(s): Thankaraj Salammal Sheena, Rajakumaran Dhivya, Venkatesan Rajiu, K. Jeganathan, Mallayan Palaniandavar, Ganesan Mathan, Mohammad Abdulkader Akbarsha
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Authors: Mookerjee S, Foster HR, Waller AK, Ghevaert CJ Abstract Platelet transfusions are given to patients in hospital who have a low blood platelet count (thrombocytopenia) either because of major bleeding (following trauma or surgery) or because the bone marrow production of platelets is impaired often due to chemotherapy, infiltration with malignant cells, fibrosis or genetic disorders. We are currently entirely reliant on blood donors as a source of platelets in transfusion medicine. However, the demand for platelets continues to rise, driven by an aging population, advances in medical procedures and ever mor...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
CONCLUSIONS: MiR-449b-5p acts as a tumor suppressor and retards the oncogenesis of glioblastoma, which is achieved via inactivation of Wnt/β-catenin signaling by directly targeting WNT2B. PMID: 32495889 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Tsujinaga S, Iwano H, Oshino T, Kadosaka T, Mizuguchi Y, Motoi K, Chiba Y, Koya T, Temma T, Kamiya K, Fukushima A, Koizumi T, Sato T, Takenaka S, Tada A, Ishizaka S, Sarashina M, Omote K, Kamada R, Konishi T, Sato T, Nagai T, Yamashita H, Anzai T Abstract Epirubicin-based chemotherapy carries a risk of inducing heart failure, although the frequency is rare. Bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody, has recently been widely used in patients with recurrent breast cancer as a first-line chemotherapeutic agent. Heart failure or arterial thromboembolism has been reported as a ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC03589K, CommunicationLongbing Ling, Haizhou Yu, Muhammad Ismail, Yan-Ping Zhu, Yuan Du, Junhui Qi An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarriers. Results have demonstrated cell membrane-like delivery system possessed an improved cellular uptake... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Cancers, Vol. 12, Pages 1477: Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers12061477 Authors: Assunta Sellitto Ylenia D’Agostino Elena Alexandrova Jessica Lamberti Giovanni Pecoraro Domenico Memoli Domenico Rocco Elena Coviello Giorgio Giurato Giovanni Nassa Roberta Tarallo Alessandro Weisz Francesca Rizzo Estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that play different roles in gene regulation and show both overlapping and specific tissue distribution patterns. ER&be...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Acosta Jaime Ruiz-Garcia Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsi...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Authors: Morhun JM, Racine NM, Guilcher GMT, Tomfohr-Madsen LM, Schulte FSM Abstract Background: The unique psychosocial needs of parents and caregivers of young children with cancer are poorly understood. The aims of the present study were to examine health-related quality of life (hrqol), stress, and psychological distress in parents of young children (0-4 years) diagnosed with cancer; and the associations between parent psychosocial functioning and child treatment characteristics. Methods: Parents (n = 35) with a child (n = 19 male, 54.3%) 0-48 months of age (median: 31.06 months) on active cancer therapy we...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
TEL AVIV, Israel, June 4, 2020 -- (Healthcare Sales &Marketing Network) -- Alpha Tau Medical, the developer of breakthrough alpha-radiation cancer therapy Alpha DaRT, is pleased to announce the closing of a Series B equity financing of $26 million. Inves... Devices, Oncology, Venture Capital Alpha Tau Medical, alpha-radiation, Alpha DaRT, radiotherapy
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
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