A comprehensive review on hepatoprotective and nephroprotective activities of chrysin against various drugs and toxic agents

Publication date: Available online 11 May 2019Source: Chemico-Biological InteractionsAuthor(s): Ravindra Babu Pingili, A. Krishnamanjari Pawar, Siva R. Challa, Tanvija Kodali, Sirisha Koppula, Vyshnavi ToletiAbstractChrysin belongs to the flavonoids and has been used as traditional medicine from ancient and has been reported to exhibit a wide range of pharmacological properties. The biochemical and molecular mechanisms involved in the hepato- and nephroprotective activities of chrysin were discussed in this review. Chrysin exhibited hepatoprotective activity against 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin, carbon tetrachloride, cisplatin, dd-galactosamine, doxorubicin, ethanol, lipopolysaccharide/dD-galactosamine, methotrexate, ammonium chloride, paracetamol, diethylnitrosamine, streptozotocin, tert-butyl hydroperoxide, thioacetamide, 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP), ischemia/reperfusion-induced hepatotoxicity and nephroprotective activity against cisplatin, doxorubicin, paracetamol, gentamicin, streptazotocin, N-nitrosodiethyl amine, 5-fluorouracil, adenine, carbon tetrachloride, copper, 2,3,7,8-tetrachlorodibenzo- p-dioxin, colistin, Nω-nitro-ll-arginine-methylester and ethanol in various animal models due to its antioxidant, anti-apoptotic activities. In this review, we provide an overview of the possible mechanisms by which chrysin reduced the hepatotoxicity and nephrotoxicity of different toxicants. This will help the toxicologists, pharmacolo...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research