Gonadal function after Busulfan compared to Treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplantation. On Behalf of the Pediatric and Transplant Complications Working Parties of EBMT

Gonadal impairment represents an important late effect occurring after hematopoietic stem cell transplantation (HSCT), affecting the quality of life of young transplanted patients. The proportion and severity of gonadal late impairment depends on type and cumulative dosage of gonadotoxic chemotherapeutic agents, type of HSCT, age at HSCT, additional use of Total Body Irradiation (TBI) for conditioning or radiotherapy (cranial and pelvic radiotherapy) administered before HSCT [1]. Gonadal complications are recognized as a consequence of myeloablative conditioning regimens, in particular based on TBI or Busulfan (Bu), and include hypergonadotropic hypogonadism and infertility.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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ConclusionsFrom the results of this study, oxaliplatin seems to incur transient decrease in sperm concentration with recovery, and some but not pronounced increase in FSH in males. The risk for infertility and hypogonadism in males and females after adjuvant oxaliplatin-based chemotherapy seems to be low to moderate, but the general recommendation of appropriate fertility conserving measures shall should not be changed.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureP. Österlund: Honoraria (self): Amgen; Honoraria (self): Bayer; Honoraria (self): Celgene; Honoraria (self...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Abstract Infertility due to genetic mutations that cause other defects, besides infertility, is defined as syndromic. Here we describe three of these disorders for which we perform genetic tests. 1) Hypopituitarism is an endocrine syndrome characterized by reduced or absent secretion of one or more anterior pituitary hormones with consequent dysfunction of the corresponding peripheral glands. Deficiencies in all the hormones is defined as pan-hypopituitarism, lack of two or more hormones is called partial hypopituitarism, whereas absence of a single hormone is defined as selective hypopituitarism. Pan-hypopituitar...
Source: Acta Bio-Medica : Atenei Parmensis - Category: General Medicine Authors: Tags: Acta Biomed Source Type: research
Serum prolactin (PRL) levels are routinely obtained in men presenting with clinical hypogonadism or infertility with mild hyperprolactinemia, often prompting pituitary magnetic resonance imaging (pitMRI) to assess for adenoma. The utility of obtaining pitMRI in this population has not been adequately studied, and no society guidelines exist to inform this decision. We hypothesize that a combination of laboratory findings predicts positive pitMRI findings in patients with mild hyperprolactinemia and, given the high rate of negative pitMRIs among young men with mild hyperprolactinemia, sought to identify patients in whom pit...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
The genetic condition is one of the most common in the UK and may be a leading cause of infertility in men. Why does it so often go untreated?Three years ago, Paul (not his real name), now 31, went to the doctor with stomach pains. His blood test came back with low testosterone levels. “We went to see a urologist and he said bluntly that we wouldn’t have any options to have kids with my sperm – we would have to use a donor or adopt,” he says. “My wife immediately burst into tears.” The couple had been trying for a child since they married in 2015. Paul was also devasta ted. “It put...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Health & wellbeing Genetics Biology Science Fertility problems Society Source Type: news
Discussion Bardet-Biedl syndrome (BBS) is a rare disorder. It is usually considered an autosomal recessive disorder but there is significant intra-familial variability. There are multiple genes (~20 currently) involved and it is believed that the phenotypic variability is due to “…differences in the total mutational load across different BBS associated genes….” It is a ciliopathy where mutation changes in proteins in the cilias causes problems in the cilia’s functioning particularly signaling. Cilia are important in signaling to maintain tissue and cellular homeostasis. Obviously screening o...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
AbstractBackgroundLower semen quality is associated with increased mortality and morbidity, which may include osteoporosis.ObjectiveTo assess whether infertile men have a lower bone mineral density (BMD) compared with fertile men at the time of fertility workup.MethodsA total of 146 men from infertile couples with unexplained impaired semen quality, characterized by sperm concentration  
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
AbstractBackgroundThis case control study aimed to investigate whether symptoms of sexual dysfunction are more common in males from infertile couples than in the general population and to explore whether symptoms of sexual dysfunction are associated to hypogonadism.ObjectivesParticipants were 165 subfertile men in infertile heterosexual relationships, 18 –50 years of age, with sperm concentrations 
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Publication date: Available online 9 July 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Christina Wei, Elizabeth CrowneAbstractChildhood cancer survivors (CCS) are at an increased risk of endocrine disorders. Disorders of the hypothalamic-pituitary-gonadal (HPG) axis are a particular concern because of their impact on pubertal development and future fertility and may be of central (hypothalamic or pituitary damage) or primary (gonadal) origin. Hypogonadism may present as pubertal disorders during adolescence and subsequent infertility in adulthood but should be anticipated to ensu...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Congenital hypogonadotropic hypogonadism (CHH) is a condition characterized by absent puberty and infertility due to gonadotropin releasing hormone (GnRH) deficiency, which is often associated with anosmia (Kallmann syndrome, KS). We identified loss-of-function heterozygous mutations in anti-M üllerian hormone (AMH) and its receptor,AMHR2, in 3% of CHH probands using whole-exome sequencing. We showed that during embryonic development, AMH is expressed in migratory GnRH neurons in both mouse and human fetuses and unconvered a novel function of AMH as a pro-motility factor for GnRH neurons. Pathohistological analysis of...
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Genetics and Genomics Source Type: research
Purpose of review To briefly summarize what is known regarding hyperprolactinemia and prolactin-secreting tumors, and review recent findings. Recent findings Prolactin was previously thought to inhibit secretion of gonadotropin-releasing hormone (GnRH) by directly inhibiting the firing of GnRH neurons, resulting in hypogonadotropic hypogonadism and infertility. However, kisspeptin has recently been implicated as the mediator of hyperprolactinemia-induced infertility, by acting upstream of the GnRH neurons as an integrator of endocrine signals. Macroprolactin is generally considered to be inactive and clinically insig...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: REPRODUCTIVE ENDOCRINOLOGY: Edited by David L. Olive Source Type: research
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