When and How to Treat Agitation in Alzheimer's Disease Dementia with Citalopram and Escitalopram

Agitation is a common neuropsychiatric symptom (NPS) in the early and middle stages of Alzheimer's disease (AD) dementia, which is difficult to treat and causes much distress. The United States Food and Drug Administration (US FDA) put out black box warnings against the use of antipsychotics in dementia in 2005 and 2008 due to the increased risk of morbidity and mortality, resulting in a reduction in antipsychotic use for treating dementia-related NPS and spurring the quest for safer and more effective pharmacological options.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Treatment in Geriatric Mental Health: Research in Action Source Type: research

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Publication date: Available online 13 July 2019Source: Journal of Herbal MedicineAuthor(s): Swati Vyas, S.L. Kothari, Sumita KachhwahaAbstractWith the rise in the ageing population in the last few decades, dementia has emerged as a serious global health issue. Alzheimer's disease (AD) is the most common type of dementia. Despite extensive drug development research, only a limited number of FDA-approved drugs are available for AD. As these drugs provide symptomatic relief only and are frequently associated with adverse effects, there remains an urgent need for developing alternative approaches to AD therapeutics. Several me...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
There hasn’t been much good news about Alzheimer’s lately, between the March announcement by Biogen and Esai that a promising trial of a potential drug treatment failed, and the July decision by Novartis and Amgen to stop their study of another class of therapies for the neurodegenerative disease. But in a pair of studies presented at the annual Alzheimer’s Association International Conference on July 14, researchers reported encouraging results from studies of non-drug approaches. In one, scientists led by Dr. Klodian Dhana at Rush University Medical Center in Chicago followed nearly 2,500 people for alm...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Brain embargoed study Source Type: news
This cohort study uses UK Biobank data to examine interactions between polygenic risk for Alzheimer disease and lifestyle (physical activity, healthy diet, moderate alcohol drinking) and their associations with incident all-cause dementia.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Authors: Schulz H, Karrasch S, Bölke G, Cyrys J, Hornberg C, Pickford R, Schneider A, Witt C, Hoffmann B Abstract The third part of the DGP statement introduces the current body of knowledge on less studied health outcomes associated with exposure to ambient air pollution: the negative impact on metabolism leading to impaired glucose tolerance and diabetes as well as contribution to the development of neurodegenerative disorders and delayed cognitive function in children. Furthermore, prenatal exposure and adverse effects on mother and child are addressed. Finally, the currently discussed biological mechanisms...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Dear Candid Caregiver: ...I don’t blame Mom because the whole thing is awful, but doing anything that increases Dad’s anxiety is a bad idea for him as well as those around him. The more Mom’s resentment about their failed dreams shows the more anxious and difficult Dad gets. The harder Dad is to care for, the more Mom’s body language and tone of voice show how on edge she is. I’m not perfect, I know, so I’m trying not to judge, but I believe that I have more distance and, for that reason, more clarity, than my mom. How do I approach Mom without upsetting her more than she already is? &nd...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Mentally stimulating activities like using a computer, playing games, crafting, and participating in social activities were associated with a lower risk of mild cognitive impairment in older people, astudy published inNeurology has found. People with mild cognitive impairment, which is not the same as dementia, may have memory loss or have difficulty following conversations or understanding complex information.Janina Krell-Roesch, Ph.D., of Mayo Clinic ’s Translational Neuroscience and Aging Laboratory, and colleagues analyzed five-year data from 2,000 participants in the population-based Mayo Clinic Study of Aging. ...
Source: Psychiatr News - Category: Psychiatry Tags: aging cognition cognitive decline healthy aging memory loss mental stimulation mild cognitive impairment social activities Source Type: research
Authors: Aga VM Abstract Agitation is a common neuropsychiatric symptom (NPS) in the early and middle stages of Alzheimer's disease (AD) dementia, which is difficult to treat and causes much distress. The U.S. Food and Drug Administration (U.S. FDA) issued black box warnings against the use of antipsychotics in dementia in 2005 and 2008 due to the increased risk of morbidity and mortality, resulting in the reduction in antipsychotic use for treating dementia-related NPS and spurring the quest for safer and more effective pharmacological options. The data favoring the use of citalopram for treating agitation in AD d...
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
New research suggests that having a relative with Alzheimer's disease may put people at risk of a premature decline in memory and learning.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Increased plasma YKL-40 has been reported in Alzheimer ’s disease (AD), but its levels in other neurodegenerative diseases are unknown. Here, we aimed to investigate plasma YKL-40 in the spectrum of neurodegene...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Short report Source Type: research
ConclusionStem cell-based disease models have the potential to induce a paradigm shift in biomedical research. In particular, the combination of the iPSC technology with recent advances in gene editing or 3D cell cultures represents a breakthrough for in vitro disease modeling and provides a platform for a better understanding of disease mechanisms in human cells and the discovery of novel therapeutics.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
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