Fluoroquinolone Use and the Risk of Collagen-Associated Adverse Events: A Systematic Review and Meta-Analysis

ConclusionsFluoroquinolone use incurs a risk of developing three collagen-associated diseases (aortic aneurysm or aortic dissection, retinal detachment, and tendon disorders). Patients at an increased risk of collagen-associated diseases should not use fluoroquinolones unless no other options are available.
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research

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Authors: Pourafkari L, Hassani-Afshar AO, Umholtz M, Sadeghpour A, Tajlil A, Li CM, Nader ND Abstract BACKGROUND: Epicardial adipose tissue (ECAT) is metabolically active and is involved in the development of atherosclerosis. The thickness of ECAT has been positively correlated with the dimensions of the ascending aorta. We aimed to examine whether ECAT thickness predicted the expansion of the aortic dimensions. METHODS: The imaging results of patients who had undergone transthoracic echocardiographic (TTE) examinations more than twice during the period 2005-2015 were surveyed. We included adult patients who ha...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Redo sternotomy in patients with arterial cardiac structures adherent to the sternum carries a risk of catastrophic bleeding. In some of those cases, particularly if they have undergone multiple previous operations deep hypothermic circulatory arrest alone may not provide sufficient time for a controlled dissection..
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
DNA and Cell Biology, Ahead of Print.
Source: DNA and Cell Biology - Category: Cytology Authors: Source Type: research
We evaluate the crimping strain, sealing stress and contact forces on a Nitinol stent deployed in the aorta during endovascular aortic (or aneurysm) repair (EVAR) procedures. Nitinol shape memory effect (SME) is used. We also study the fluid-structure interaction (FSI) of the blood flow on the stented aorta.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Authors: Yiğit G, Çetinkaya F, Aytekin B, Türkçü MA, Özen A, Sarıtaş A PMID: 31708991 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
Authors: Borek A, Drzymała F, Botor M, Auguściak-Duma AM, Sieroń AL Abstract Abdominal aortic aneurysm (AAA) is a dangerous condition involving pathological dilation of the aortic wall. Due to the asymptomatic course of this disease and the dangerous consequences of its rupture, it is important to identify its specific bio-markers expressed as early as possible. Different expression profiles of microRNAs (miRNAs) were detected in patients diagnosed with AAA. MicroRNAs are small non-coding RNA molecules that regulate the expression of other genes at the translation stage. miRNAs affecting translation can lead to abn...
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
ConclusionOur experience and the results obtained with this new perioperative protocol with epidural corticosteroid and accurate hemodynamic control have been encouraging and it seems a valid proposal to be explored in future by well-structured prospective, randomized protocols.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
An infected aneurysm of the thoracic aorta is a rare clinical condition with significant morbidity and mortality. Patients with fast-growing aortic aneurysms show a high incidence of rupture. Gram-positive org...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
Elucidating critical aortic diameters at which natural complications occur (rupture, dissection, death) is paramount to guide timely surgical intervention. Natural history knowledge for descending thoracic or thoracoabdominal aortic aneurysms (DTTAA) is sparse. Our small early studies recommended repairing DTTAAs before a critical diameter of 7.0cm. Here we focus exclusively on a large number of DTTAAs followed over time, enabling more detailed analysis with greater granularity across aortic sizes.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
An ageing population leads to more age related diseases, such as complex abdominal aortic aneurysms (AAA). Patients with complex AAAs and multiple comorbidities benefit from fenestrated endovascular aneurysm repair (FEVAR), but for the elderly this benefit is not completely clear.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
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