Fluoroquinolone Use and the Risk of Collagen-Associated Adverse Events: A Systematic Review and Meta-Analysis
ConclusionsFluoroquinolone use incurs a risk of developing three collagen-associated diseases (aortic aneurysm or aortic dissection, retinal detachment, and tendon disorders). Patients at an increased risk of collagen-associated diseases should not use fluoroquinolones unless no other options are available.
Authors: Pourafkari L, Hassani-Afshar AO, Umholtz M, Sadeghpour A, Tajlil A, Li CM, Nader ND Abstract BACKGROUND: Epicardial adipose tissue (ECAT) is metabolically active and is involved in the development of atherosclerosis. The thickness of ECAT has been positively correlated with the dimensions of the ascending aorta. We aimed to examine whether ECAT thickness predicted the expansion of the aortic dimensions. METHODS: The imaging results of patients who had undergone transthoracic echocardiographic (TTE) examinations more than twice during the period 2005-2015 were surveyed. We included adult patients who ha...
Redo sternotomy in patients with arterial cardiac structures adherent to the sternum carries a risk of catastrophic bleeding. In some of those cases, particularly if they have undergone multiple previous operations deep hypothermic circulatory arrest alone may not provide sufficient time for a controlled dissection..
DNA and Cell Biology, Ahead of Print.
We evaluate the crimping strain, sealing stress and contact forces on a Nitinol stent deployed in the aorta during endovascular aortic (or aneurysm) repair (EVAR) procedures. Nitinol shape memory effect (SME) is used. We also study the fluid-structure interaction (FSI) of the blood flow on the stented aorta.
Authors: Yiğit G, Çetinkaya F, Aytekin B, Türkçü MA, Özen A, Sarıtaş A PMID: 31708991 [PubMed]
Authors: Borek A, Drzymała F, Botor M, Auguściak-Duma AM, Sieroń AL Abstract Abdominal aortic aneurysm (AAA) is a dangerous condition involving pathological dilation of the aortic wall. Due to the asymptomatic course of this disease and the dangerous consequences of its rupture, it is important to identify its specific bio-markers expressed as early as possible. Different expression profiles of microRNAs (miRNAs) were detected in patients diagnosed with AAA. MicroRNAs are small non-coding RNA molecules that regulate the expression of other genes at the translation stage. miRNAs affecting translation can lead to abn...
ConclusionOur experience and the results obtained with this new perioperative protocol with epidural corticosteroid and accurate hemodynamic control have been encouraging and it seems a valid proposal to be explored in future by well-structured prospective, randomized protocols.
An infected aneurysm of the thoracic aorta is a rare clinical condition with significant morbidity and mortality. Patients with fast-growing aortic aneurysms show a high incidence of rupture. Gram-positive org...
Elucidating critical aortic diameters at which natural complications occur (rupture, dissection, death) is paramount to guide timely surgical intervention. Natural history knowledge for descending thoracic or thoracoabdominal aortic aneurysms (DTTAA) is sparse. Our small early studies recommended repairing DTTAAs before a critical diameter of 7.0cm. Here we focus exclusively on a large number of DTTAAs followed over time, enabling more detailed analysis with greater granularity across aortic sizes.
An ageing population leads to more age related diseases, such as complex abdominal aortic aneurysms (AAA). Patients with complex AAAs and multiple comorbidities benefit from fenestrated endovascular aneurysm repair (FEVAR), but for the elderly this benefit is not completely clear.