Genetic study on small insertions and deletions in psoriasis revealed an important impact on complex human diseases

Genetic studies based on single nucleotide polymorphisms (SNPs) have provided valuable insights into the genetic architecture of complex diseases. However, a large fraction of heritability for most of these diseases remains unexplained, and the impact of small insertions and deletions (InDels) has been neglected.We performed a comprehensive screen on exome sequence data of 1,326 genes using the SOAP-PopIndel method for InDels in 32,043 Chinese Han individuals and identified 29 unreported InDels within 25 susceptibility genes associated with psoriasis.

Source: Journal of Investigative Dermatology - May 9, 2019 Category: Dermatology Authors: Qi Zhen, Zhenjun Yang, Wenjun Wang, Bao Li, Mingzhou Bai, Jing Wu, Huiyao Ge, Zirui Dong, Juan Shen, Huayang Tang, Silong Sun, Ying Qiu, Jinjin Xu, Xiaoxiao Qu, Ying Wang, Meihui Yi, Huaqing Hu, Yuanhong Xu, Hui Cheng, Bo Liang, Jinping Gao, Haojing Shao, Tags: Original Article Source Type: research