Improved Diagnosis and Treatment of Anaphylaxis in a Pediatric Emergency Department (2013-2018)

Publication date: Available online 10 May 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Neta Cohen, Tali Capua, Dikla Pivko–Levy, Moshe Ben–Shoshan, Ayelet Rimon, Shira Benor
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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Conclusions: COS showed anti-allergy properties by regulating the levels of Th1 and Th2 cytokines.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Many notable advances in drug allergy, urticaria, angioedema and anaphylaxis were reported in 2018. Broad spectrum antibiotic use and consequently antibiotic resistance is widespread, and algorithms to clarify β-lactam allergy and optimize antibiotic use were described. Meaningful data emerged on the pathogenesis of delayed drug hypersensitivity reactions. Progress not only in defining biomarkers, but also in understanding the impact on quality of life and developing better treatments have been made for individuals with chronic idiopathic urticaria.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
In this study, caffeine was evaluated for anti-degranulation activity using basophilic cell line RBL-2H3 cells as the in vitro model and the passive cutaneous anaphylaxis (PCA) model mice in vivo. As a result, caffeine effectively suppressed antigen-induced degranulation by RBL-2H3 cells in a dose-dependent manner without cytotoxicity. Besides, caffeine also inhibited FcεRI-mediated intracellular signaling pathways, such as phosphorylation of Syk, Btk, PLCγ1, PI3K, and Akt in antigen-stimulated RBL-2H3 cells. Caffeine also suppressed PCA response in mice.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 24 May 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Gabriel Gastaminza, Miguel Ruiz-Canela, Blanca Andrés-López, María J. Barasona Villarejo, Rosario Cabañas, Ignacio García-Núñez, María José Goikoetxea, José Julio Laguna, Teófilo Lobera, Marta López-San Martín, Joaquín Martín-Lázaro, Ruth Mielgo-Ballesteros, Esther Moreno, María del Carmen Moya-Quesada, Nancy Ortega-Rodríguez, Patricia Rojas-Perez-Ezquerra, Ana Rosado, Mar&iacu...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
AbstractWhile acute allergic symptoms can be managed by emergency medication, to date, allergen-specific immunotherapy (SIT) with allergen extracts is the only available curative treatment option. However, the risk of anaphylactic reactions, long treatment duration, varying extract quality, and underrepresentation of certain allergens currently prevent many patients from successfully undergoing SIT. Novel strategies are needed to enhance efficacy, safety, and convenience of allergy treatment. Fusion proteins combining allergen and adjuvant into a single molecule can efficiently induce immune responses by targeting the alle...
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research
Hymenoptera venom allergy ranks among the top three causes of anaphylaxis worldwide, and approximately one quarter of sting-induced reactions are classified as severe. Fatal sting reactions are exceedingly rare, but certain factors may entail a considerabl...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news
We review the history of the classification and coding changes for anaphylaxis and provide current and perspective information in the field. In 2012, an analysis of Brazilian data demonstrated undernotification of anaphylaxis-related deaths because of the difficulties of coding using the International Classification of Diseases, 10th Revision. This work triggered strategic international actions supported by the Joint Allergy Academies and the International Classification of Diseases World Health Organization (WHO) leadership to update the classification of allergic disorders for the International Classification of Diseases...
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Review article Source Type: research
PMID: 31228627 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Food-dependent exercise-induced anaphylaxis (FDEIA) is characterized by anaphylaxis that occurs during or shortly after exercise following ingestion of specific foods to which a patient is sensitized. Independently, exercise and food are well tolerated.1 Described mostly in adolescents and young adults, it has an estimated 0.02% prevalence and several trigger foods have been reported.1-3 We will describe a case in which tomato was found to be the culprit food and the diagnostic approach used for this patient.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Diphtheria, tetanus, and pertussis vaccination is an integral component of the pediatric immunization schedule with DTaP administered to patients as a primary series at 2, 4 and 6 months of age and booster doses at 15 – 18 months and 4-6 years of age. A single Tdap dose is recommended at 11 to 12 years old. Per the CDC, contraindications to DTaP and Tdap vaccination include anaphylaxis after a previous dose or to a vaccine component and encephalopathy within 7 days of administration.1 Anaphylactic reactions to vaccines are rare, occurring at a rate of approximately 1 per one million doses administered.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
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