Editorial: Better Treatments and the Importance of Publishing Negative Clinical Trials

We need better treatments for children with mental health problems, particularly those struggling with depression and suicidality. Every reader of this editorial already knows this. While our best treatments help many children and adolescents, some experience only modest improvements such that they are still burdened with much of the weight of mental illness. And some experience no benefit at all. These conclusions are supported by two recent meta analytic studies. In a comprehensive meta-analysis of the efficacy of treatments for anxiety, attention-deficit/hyperactivity disorder, conduct problems, and depression, outcomes for depression were the “most disappointing” with effect sizes of only .29 at post treatment assessments.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Editorial Source Type: research

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ConclusionPhysical exercise intervention in combination with cognitive behavioral therapy for individuals with Internet gaming disorder seems to improve the severity of internet use and depressive mood and enhance left prefrontal activation.Graphical abstract
Source: Mental Health and Physical Activity - Category: Psychiatry & Psychology Source Type: research
Atopic dermatitis (AD) impacts up to 20% of children worldwide (1;2). Children with AD experience physical discomfort, poorer quality of life (3-5), increased behavior problems (6;7), higher frequency of attention-deficit/hyperactivity disorder (ADHD) (8-11) and higher healthcare utilization (12). Parents of children with AD report decreased quality of life (13-16), negative impact on the family (14;17), increased depression and anxiety (16), and increased work absenteeism (18;19).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
ConclusionThis is an exemplary case of anFMR1 premutation carrier with significant psychiatric and cognitive issues that demonstrates Fragile X ‐associated Neuropsychiatric Disorders (FXAND) as separate from the other well‐known premutation disorders.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research
This study is a single-center, randomized, double-blind, placebo-controlled, and investigator-initiated clinical trial. A total of 60 patients between 7 and 65 years of age with AD and respiratory disorders who received a diagnosis of AD by Hanifin and Rajka criteria who scored 15 to 50 in a scoring atopic dermatitis (SCORAD) will be enrolled. Participants will be randomly assigned to the SCRT or placebo group in a ratio of 1:1 and they will have a visit schedule comprising 4 visits including a screening visit during 8 to 10 weeks. The participants will be administered SCRT or placebo 3 times a day for 4 weeks. The primary...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
CONCLUSIONS: Adult ADHD is common in a Malaysian forensic mental hospital and is associated with unmarried status, alcohol abuse, lifetime manic/hypomanic episodes, generalised anxiety disorder, and younger age at first offence. PMID: 31871308 [PubMed - in process]
Source: East Asian Archives of Psychiatry - Category: Psychiatry Tags: East Asian Arch Psychiatry Source Type: research
This study evaluated the impact of tic disorders and comorbid symptoms on individual and parent quality of life (QoL) and family functioning.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Research Paper Source Type: research
In this report, we describe the prevalence and disease burden of each mental disorder for the states of India, from 1990 to 2017.MethodsWe used all accessible data from multiple sources to estimate the prevalence of mental disorders, years lived with disability (YLDs), and disability-adjusted life-years (DALYs) caused by these disorders for all the states of India from 1990 to 2017, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We assessed the heterogeneity and time trends of mental disorders across the states of India. We grouped states on the basis of their Socio-demographic Index (SDI), whi...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Epidemiological studies demonstrate an association between asthma and mental health disorders, although little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetics and the causal link between asthma and mental health disorders. We conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between asthma from the UK Biobank and eight mental health disorders from the Psychiatric Genomics Consortium: attention deficit hyperactivity disorder (ADHD), anxiety disorder (ANX), autism spectrum disorder, bipolar disorder, eating diso...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Psychiatric medications are an important part of treatment for many people with mental disorders, such as depression, bipolar disorder, ADHD, schizophrenia, anxiety, and others. They play an important role in helping to alleviate the most serious symptoms, allowing people to better focus on their lives and on other treatment types, such as psychotherapy. Psychiatric medications are an important part of many people’s treatment plans for obtaining the most effective treatment for a mental health concern or mental illness. It’s good to know what drugs are being prescribed most often for mental disorders in the U.S...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Medications Psychiatry psychiatric meds psychiatric prescriptions Source Type: blogs
Publication date: Available online 14 December 2019Source: International Review of NeurobiologyAuthor(s): Alexandra Lautarescu, Michael C. Craig, Vivette GloverAbstractThe impact of stress on brain health begins in the womb. Both animal and human studies have found that prenatal maternal stress affects the brain and behavior of the offspring. Stressful life events, exposure to a natural disaster, and symptoms of maternal anxiety and depression increase the risk for the child having a range of emotional, behavioral and/or cognitive problems in later life. These include depression, anxiety, Attention Deficit Hyperactivity Di...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
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