Brain (18)F-FDG and (11)C-PiB PET findings in two siblings with FTD/ALS associated with the C9ORF72 repeat expansion.

We describe a patient in whom early clinical evaluation, MRI and fluorodeoxyglucose (FDG) positron emission tomography (PET) findings failed to definitively differentiate between FTD and Alzheimer's disease (AD), whereas (11)C-Pittsburgh compound B (PiB) PET was negative for amyloid pathology. He later developed ALS symptoms, and post mortem neuropathological findings were diagnostic of FTD-ALS, while no findings suggested AD. His sister was diagnosed with FTD, and the C9ORF72 expansion was detected in both siblings. We conclude that (11)C-PiB PET imaging may help the early differential diagnosis between AD and FTD, including C9FTD/ALS. PMID: 23216213 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/PubMed/23216213?dopt=Abstract

Source: Neurocase - December 5, 2012 Category: Neurology Authors: Martikainen MH, Gardberg M, Jansson L, Röyttä M, Rinne JO, Kaasinen V Tags: Neurocase Source Type: research