Effect of a multistrain probiotic on cognitive function and risk of falls in patients with cirrhosis: a randomized trial - Rom án E, Nieto JC, Gely C, Vidal S, Pozuelo M, Poca M, Juárez C, Guarner C, Manichanh C, Soriano G.

Probiotics can modulate gut microbiota, intestinal permeability, and immune response and could therefore improve cognitive dysfunction and help avoid potential consequences, such as falls, in patients with cirrhosis. The aim of this study was to evaluate t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

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Authors: Niewiński G, Graczyńska A, Morawiec S, Raszeja-Wyszomirska J, Wójcicki M, Zieniewicz K, Główczyńska R, Grąt M Abstract BACKGROUND Orthotopic liver transplantation (OLT) is the standard of care for end-stage liver disease. The Charlson Comorbidity Index (CCI) was originally created to assess the survival rate of patients with chronic diseases, although it was modified and adopted in OLT recipients as CCI-OLT. MATERIAL AND METHODS In total of 248 consecutive liver transplant recipients with viral cirrhosis in 98 (39.5%) patients were included. CCI-OLT was calculated assigning a weight of 3...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Schweighardt AE, Juba KM Abstract Acetaminophen is among the most commonly used nonopioid analgesics, but significant variation exists in its prescribing practices for cirrhosis patients. Our primary objective was to describe the quality of evidence supporting or refuting the use of acetaminophen in patients with hepatic dysfunction. A comprehensive literature review of PubMed, Cochrane Library, Web of Science, and International Pharmaceutical Abstracts using the search terms "acetaminophen," "paracetamol," "chronic liver disease," "cirrhosis," and "hepatic dise...
Source: Journal of Pain and Palliative Care Pharmacotherapy - Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research
In their recent study comparing different assays to measure albumin level, van de Logt et  al.1 show that the use of bromocresol green (BCG) (but not bromocresol purple [BCP]) leads to a substantial overestimation of plasma and serum albumin concentration (mean bias: 6.2 g/l), in comparison to the reference immunonephelometric assay in patients with hypoalbuminemia (including patients w ith membranous nephropathy, liver cirrhosis, or sepsis) and in chronic kidney disease patients with albumin concentrations within reference values.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Condition:   Compensated Cirrhosis Intervention:   Diagnostic Test: esophagogastroduodenoscopy Sponsors:   Nanfang Hospital of Southern Medical University;   Southern Medical University, China;   LanZhou University;   Zhongda Hospital, Medical School, Southeast University;   Guangdong Second Provincial General Hospital;   Xingtai People's Hospital;   The Third Hospital of Zhenjia ng Affiliated Jiangsu University;   Tianjin Second People's Hospital;   Zhejiang U...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsThese results reveal that XT promotes gastrointestinal motility by acting on multiple targets in multiple pathways, of which the L-arginine/NO pathway is most affected.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: Although HCC occurrence after DAAs was not high, recurrence was apparently high. Pretreatment alpha-fetoprotein is a predictor for de novo HCC. The time between HCC ablation and DAAs was the strongest predictor of recurrence.Dig Dis
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
Conclusion: A combination therapy of tolvaptan and furosemide enabled furosemide dose reductions. Systematic reductions of the furosemide doses can lead to the improvement of renal function.Dig Dis
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is the commonest form of liver disease in primary care, with rates up to 25%.1 This figure, however, encompasses the whole spectrum of NAFLD from simple steatosis, non-alcoholic steatohepatitis (NASH) through to advanced fibrosis/cirrhosis. Due to the strong association with liver-related morbidity and premature death,2,3 fibrosis has become the main focus in secondary care for risk stratification, targeted lifestyle and metabolic risk management and drug trial recruitment.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research
AbstractBackgroundSince there is no reliable evidence on the safety of pancreaticoduodenectomy (PD) in chronic hepatic dysfunction (CHD) including liver cirrhosis (LC), the effects of CHD on patients undergoing PD were investigated.MethodsThis multi ‐institutional retrospective study analyzed 529 patients with CHD, including 105 patients diagnosed with LC, who underwent PD at 82 high‐volume institutions between 2004 and 2013.ResultsThe in ‐hospital mortality rate was 5.9%. The incidence of postoperative hepatic decompensation upon discharge and refractory ascites was 10.2% and 8.9%, respectively. For hepatic decompen...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - Category: Surgery Authors: Tags: Original Article Source Type: research
Conditions:   Liver Cirrhosis;   Esophageal Varices;   Liver Stiffness Intervention:   Diagnostic Test: Gastroscopy Sponsor:   West China Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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