Salvage treatment in recurrent endometrial cancer of the pelvis and peritoneal cavity

Publication date: Available online 10 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Lindsey A. McAlarnen, Kelly Ryan, William Adams, Adam Gliniewicz, Abigail D. Winder, Margaret R. Liotta, Ronald K. Potkul, William Small, Matthew M. HarkenriderAbstractRegional recurrence of endometrial cancer is a challenging yet potentially curable group of patients without defined standard of care. Our aim is to determine optimal methods of salvage therapy for regionally recurrent endometrial cancer.Twenty-two cases of nodal, pelvic, or peritoneal cavity recurrences of endometrial cancer were identified from a single institution database. Univariable Cox proportional hazards models were used to estimate the risk of a second recurrence or death. Kaplan-Meier plots were used to estimate the probability of progression free survival and overall survival among patients in three cohorts: Multimodality therapy (surgery, chemo, and radiotherapy +/− vaginal brachytherapy), non-surgery (chemotherapy or EBRT, or both), and surgery cohort (surgery +/− chemo OR EBRT).Thirteen recurrences (59%) were regional including the pelvic and paraaortic nodes, while nine recurrences (41%) were abdominal. For the entire cohort, the probability of progression free survival at 2 years was 51% (95% CI, 26% - 72%). The 2-year probability of progression free survival was 62% in the multimodality cohort, 40% in the non-surgery cohort, and 38% in the surgery cohort. The 2-year probability of overall surviva...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research