Genetic analysis of ring finger protein 213 (RNF213) c.14576G > A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease.

CONCLUSIONS: In contrast to MMD patients, the prevalence of RNF213 c.14576G>A polymorphism was significantly lower in patients with intracranial VAD. The RNF213 gene polymorphism may preferentially affect the cerebrovascular lesion in the anterior circulation, which is originated from the primitive internal carotid arteries. The genetic background underlying intracranial VAD should be elucidated in future studies.
ABBREVIATIONS: VAD: vertebral artery dissection; MMD: moyamoya disease; RNF213: ring finger protein 213; CAD: carotid artery dissection.
PMID: 31064275 [PubMed - as supplied by publisher]

Source: Neurological Research - May 10, 2019 Category: Neurology Tags: Neurol Res Source Type: research